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insulin like growth factor binding protein 3

Summary

Gene Symbol

IGFBP3

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 282261
PubChem: 282261

Annotation

Keyword

Apoptosis
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor binding
Phosphoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
I6XXP7
P20959

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
apoptotic process
response to insulin
positive regulation of apoptotic process
regulation of insulin-like growth factor receptor signaling pathway	IEA	30032202
positive regulation of myoblast differentiation

GO Hierarchy

biological process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of insulin-like growth factor receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of myoblast differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of insulin-like growth factor receptor signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of myoblast differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	22301074
extracellular space	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
fibronectin binding	IEA	30032202
protein tyrosine phosphatase activator activity
insulin-like growth factor I binding	IEA	30032202
insulin-like growth factor II binding	IEA	30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

fibronectin binding

growth factor binding [inference]

insulin-like growth factor binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

phosphatase regulator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

protein phosphatase regulator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

insulin-like growth factor binding

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
fibronectin binding
growth factor binding
insulin-like growth factor I binding
insulin-like growth factor II binding
insulin-like growth factor binding
regulation of insulin-like growth factor receptor signaling pathway

Displaying **all 7** entries
InterPro
Growth factor receptor cysteine-rich domain superfamily
Insulin-like growth factor binding protein 3
Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
Insulin-like growth factor-binding protein family 1-6, chordata
Insulin-like growth factor-binding protein, IGFBP
Thyroglobulin type-1 superfamily
Thyroglobulin type-1

Ortholog

Displaying entries **1 - 10** of 60 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	3486	HUMAN88882
Mus musculus	16009	MOUSE07065
Rattus norvegicus	24484	RATNO09131
Danio rerio	403079	DANRE18768
Sus scrofa	448812	PIGXX12944
Pan troglodytes	463396	PANTR40216
Macaca mulatta	696868	MACMU33268
Equus caballus	100034155	HORSE32267
Ornithorhynchus anatinus	100076387	ORNAN19486
Pongo abelii	100173070	PONAB32408