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Guidelines

MIRAGE

mannosidase alpha class 2B member 1

Summary

Gene Symbol

MAN2B1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 282272
KEGG Gene ID: bta:282272
PubChem: 282272

Annotation

Keyword

3D-structure
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Glycosidase
Lysosome
Metal-binding
Reference proteome
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q29451	Lysosomal acid alpha-mannosidase Mannosidase alpha class 2B member 1 Mannosidase alpha-B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mannose metabolic process	IEA	22301074
learning or memory
oligosaccharide catabolic process
protein modification process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

catabolic process [inference]

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

oligosaccharide metabolic process [inference]

oligosaccharide catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

protein metabolic process [inference]

protein modification process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

oligosaccharide metabolic process [inference]

oligosaccharide catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process

macromolecule modification [inference]

protein modification process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular space
nucleoplasm
lysosome	IEA	30032202
lysosomal lumen

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
alpha-mannosidase activity	IEA	22301074 30032202
zinc ion binding
carbohydrate binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity [inference]

alpha-mannosidase activity

binding [inference]

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha mannosidase

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 6** entries
Gene Ontology
alpha-mannosidase activity
catalytic activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity
mannose metabolic process
metal ion binding

Displaying **all 9** entries
InterPro
Galactose mutarotase-like domain superfamily
Glycoside hydrolase 38, N-terminal domain superfamily
Glycoside hydrolase families 57/38, central domain superfamily
Glycoside hydrolase family 38, N-terminal domain
Glycoside hydrolase family 38, central domain superfamily
Glycoside hydrolase family 38, central domain
Glycoside hydrolase/deacetylase, beta/alpha-barrel
Glycosyl hydrolase family 38, C-terminal
Glycosyl hydrolase, all-beta

KEGG BRITE Database

Orthology

K12311

Name

lysosomal alpha-mannosidase [EC:3.2.1.24]

References

19722277

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R08717	3.2.1.24	G88469YE	G47023PF
R08718	3.2.1.24	G31265VL	G24464VD

Ortholog

Displaying entries **31 - 40** of 66 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Chinchilla lanigera	102017332		CHILA05021
Macaca fascicularis	102137710		MACFA17328
Capra hircus	102183410		CAPHI28325
Astyanax mexicanus	103033201		ASTMX14521
Ornithorhynchus anatinus	103170598		ORNAN29744
Chlorocebus sabaeus	103233978		CHLSB15334
Carlito syrichta	103250460		CARSF28267
Rhinopithecus roxellana	104661102		RHIRO03259
Pteropus vampyrus	105307155		PTEVA02361
Macaca nemestrina	105467373		MACNE12095

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025