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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Summary

Gene Symbol

PFKFB1

Organism

Bos taurus (cattle)

External Links

NCBI Gene: 282304
KEGG Gene ID: bta:282304
PubChem: 282304

Annotation

Keyword

ATP-binding
Acetylation
Hydrolase
Kinase
Multifunctional enzyme
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P49872	6PF-2-K/Fru-2,6-P2ase liver isozyme

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
fructose metabolic process	IEA	22301074
fructose 2,6-bisphosphate metabolic process	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

carbohydrate derivative metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	IEA	30032202
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex

cellular anatomical entity [inference]

cytosol

Displaying **all 3** entries
GO Term	Evidence Code	PMID
fructose-2,6-bisphosphate 2-phosphatase activity	IEA	30032202
ATP binding	IEA	22301074 30032202
6-phosphofructo-2-kinase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

carbohydrate kinase activity [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

fructose-2,6-bisphosphate 2-phosphatase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K19028

Name

6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 [EC:2.7.1.105 3.1.3.46]

References

8814283

Ortholog

Displaying entries **31 - 40** of 56 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	24638		RATNO44230
Cavia porcellus	100722672		CAVPO24133
Octodon degus	101574648		OCTDE26516
Monodelphis domestica	100014887		MONDO36409
Anolis carolinensis	100563845		ANOCA01513
Ursus maritimus	103682099		URSMA33079
Bos indicus x Bos taurus	113886938		BOBOX23342
Otolemur garnettii	100963075		OTOGA00286
Chinchilla lanigera	102025351		CHILA17473
Aotus nancymaae	105730482		AOTNA37253

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024