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Fas cell surface death receptor

Summary

Gene Symbol

FAS

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 282488
PubChem: 282488

Annotation

Keyword

Apoptosis
Calmodulin-binding
Cell membrane
Disulfide bond
Glycoprotein
Palmitate
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P51867	Apo-1 antigen Apoptosis-mediating surface antigen FAS FASLG receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
activation-induced cell death of T cells	IEA	30032202
immune response	IEA	22301074
regulation of stress-activated MAPK cascade	IEA	30032202
negative regulation of apoptotic process	IEA	30032202
motor neuron apoptotic process	IEA	30032202

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

signal transduction in absence of ligand [inference]

extrinsic apoptotic signaling pathway in absence of ligand

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

necroptotic signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

motor neuron apoptotic process

leukocyte apoptotic process [inference]

lymphocyte apoptotic process [inference]

T cell apoptotic process [inference]

activation-induced cell death of T cells

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

signal transduction in absence of ligand [inference]

extrinsic apoptotic signaling pathway in absence of ligand

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

necroptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

Displaying **all 3** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IEA	30032202
CD95 death-inducing signaling complex	IEA	30032202
membrane raft	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

death-inducing signaling complex [inference]

CD95 death-inducing signaling complex

cellular anatomical entity [inference]

membrane [inference]

membrane microdomain [inference]

membrane raft

side of membrane [inference]

external side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
tumor necrosis factor receptor activity	IEA	30032202
protein binding	IEA	22301074
calmodulin binding

GO Hierarchy

molecular function

binding [inference]

protein binding

calmodulin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

death receptor activity [inference]

tumor necrosis factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tumor necrosis factor receptor superfamily member 6

Functional Category

I: Lipid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
activation-induced cell death of T cells
calmodulin binding
extrinsic apoptotic signaling pathway in absence of ligand
immune response
motor neuron apoptotic process
necroptotic signaling pathway
regulation of apoptotic process
regulation of stress-activated MAPK cascade

Displaying **all 6** entries
InterPro
Death domain
Death-like domain superfamily
Fas receptor, N-terminal
Fas receptor, death domain
Fas receptor
TNFR/NGFR cysteine-rich region

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	355	HUMAN02087
Mus musculus	14102	MOUSE25392
Rattus norvegicus	246097	RATNO18988
Canis lupus familiaris	486469	CANLF10679
Felis catus	493881	FELCA26636
Pan troglodytes	738331	PANTR01106
Danio rerio	768248	DANRE12971
Equus caballus	100071639	HORSE15953
Ovis aries	100144426	SHEEP11422
Pongo abelii	100173848	PONAB01080