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glycoprotein M6B

Summary

Gene Symbol

GPM6B

Organism

Homo sapiens (human)

External Links

NCBI Gene

2824

PubChem

2824

Alliance of Genome Resources

HGNC:4461

Annotation

Keyword

Alternative splicing
Cell membrane
Coiled coil
Developmental protein
Differentiation
Glycoprotein
Neurogenesis
Osteogenesis
Phosphoprotein
Protein transport
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q13491
Q59FD5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
ossification	IEA
nervous system development	NAS	8661015
protein transport	IEA
central nervous system myelination	IBA
positive regulation of bone mineralization	IMP	21638316

GO Hierarchy

biological process

cellular process [inference]

ensheathment of neurons [inference]

axon ensheathment [inference]

axon ensheathment in central nervous system [inference]

central nervous system myelination

myelination [inference]

central nervous system myelination

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

axon development

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly

multicellular organismal process [inference]

ossification

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter uptake [inference]

negative regulation of serotonin uptake

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter uptake [inference]

negative regulation of neurotransmitter uptake [inference]

negative regulation of serotonin uptake

regulation of serotonin uptake [inference]

negative regulation of serotonin uptake

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter uptake [inference]

negative regulation of serotonin uptake

regulation of cellular localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

regulation of protein localization to cell surface [inference]

negative regulation of protein localization to cell surface

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

negative regulation of transport [inference]

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter uptake [inference]

negative regulation of serotonin uptake

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

regulation of focal adhesion assembly

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

negative regulation of cellular process [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of cell-substrate junction organization [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of cellular localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

regulation of protein localization to cell surface [inference]

negative regulation of protein localization to cell surface

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of ossification [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	IBA
myelin sheath	IBA
membrane raft	ISS
membrane raft	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane microdomain [inference]

membrane raft

myelin sheath

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
structural constituent of myelin sheath	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of myelin sheath

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

neuronal membrane glycoprotein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
neuron projection development

Displaying **all 2** entries
InterPro
Myelin proteolipid protein PLP, conserved site
Myelin proteolipid protein PLP

Ortholog

Displaying entries **11 - 20** of 86 in total

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Species	Gene ID	Orthologous MAtrix
Bos taurus	516689	BOVIN37453
Macaca mulatta	711762	MACMU47695
Monodelphis domestica	100031896	MONDO31547
Equus caballus	100050640	HORSE43943
Ornithorhynchus anatinus	100084943	ORNAN06656
Sus scrofa	100155237	PIGXX36935
Pongo abelii	100173640	PONAB37274
Taeniopygia guttata	100230860	TAEGU11161
Callithrix jacchus	100402221	CALJA47326
Ailuropoda melanoleuca	100484467	AILME04346