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NPC intracellular cholesterol transporter 2, tandem duplicate 1

Summary

Gene Symbol

npc2.1

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

282673

PubChem

282673

Alliance of Genome Resources

ZFIN:ZDB-GENE-021206-13

Annotation

Keyword

Cholesterol metabolism
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Lipid transport
Lysosome
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A8M9PE29	Epididymal secretory protein E1
Q9DGJ3	16.5 kDa secretory protein Epididymal secretory protein E1 Niemann Pick type C2 protein homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
lipid metabolic process	IEA
lipid transport	IEA
inflammatory response	IMP	33986646
nervous system development	IEA
central nervous system development	IMP	33722902

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

steroid metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process

steroid metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

blood circulation

behavior [inference]

motor behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

notochord morphogenesis

embryonic morphogenesis [inference]

embryonic organ morphogenesis [inference]

notochord morphogenesis

anatomical structure formation involved in morphogenesis [inference]

otolith formation

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

otic vesicle development

tube development [inference]

otic vesicle development

animal organ development [inference]

sensory organ development [inference]

otic vesicle development

system development [inference]

inner ear development [inference]

otic vesicle development

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

organic substance transport [inference]

lipid transport

sterol transport

cholesterol transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

organic hydroxy compound transport [inference]

sterol transport

cholesterol transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
lysosome	IEA
endoplasmic reticulum	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cholesterol binding	IBA
sterol binding	IEA

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

steroid binding [inference]

sterol binding

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

NPC intracellular cholesterol transporter 2 a

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
intracellular cholesterol transport
sterol transport

Displaying **all 3** entries
InterPro
Immunoglobulin E-set
MD-2-related lipid-recognition domain
Sterol transport protein NPC2-like

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10577	Xenbase:XB-GENE-6258064	HUMAN20282
Xenopus tropicalis	33374	Xenbase:XB-GENE-6258064
Mus musculus	67963	Xenbase:XB-GENE-6258064	MOUSE07648
Bos taurus	280815		BOVIN01723
Xenopus tropicalis	282673	Xenbase:XB-GENE-6258064
Rattus norvegicus	286898		RATNO35263
Sus scrofa	397410		PIGXX32827
Canis lupus familiaris	403920		CANLF18082
Macaca mulatta	699881		MACMU42814
Ovis aries	100037669		SHEEP18462

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements