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scavenger receptor cysteine rich family member with 5 domains

Summary

Gene Symbol

SSC5D

Organism

Homo sapiens (human)

External Links

NCBI Gene

284297

PubChem

284297

Alliance of Genome Resources

HGNC:26641

Annotation

Keyword

Alternative splicing
Cytoplasm
Developmental protein
Disulfide bond
Glycoprotein
Innate immunity
Receptor
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
A1L4H1	Soluble scavenger protein with 5 SRCR domains

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
defense response	IBA
vesicle-mediated transport	IEA
negative regulation of interleukin-8 production	ISS
detection of bacterial lipoprotein	ISS
detection of bacterial lipoprotein	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

vesicle-mediated transport

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin [inference]

detection of bacterial lipoprotein

response to bacterial lipoprotein [inference]

detection of bacterial lipoprotein

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of bacterial lipoprotein

response to biotic stimulus [inference]

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of bacterial lipoprotein

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin [inference]

detection of bacterial lipoprotein

response to bacterial lipoprotein [inference]

detection of bacterial lipoprotein

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of bacterial lipoprotein

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin [inference]

detection of bacterial lipoprotein

response to bacterial lipoprotein [inference]

detection of bacterial lipoprotein

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of bacterial lipoprotein

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of bacterial lipoprotein

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

regulation of interleukin-8 production [inference]

negative regulation of interleukin-8 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

regulation of interleukin-8 production [inference]

negative regulation of interleukin-8 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

regulation of interleukin-8 production [inference]

negative regulation of interleukin-8 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

regulation of interleukin-8 production [inference]

negative regulation of interleukin-8 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

regulation of interleukin-8 production [inference]

negative regulation of interleukin-8 production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-8 production

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular space	ISS
extracellular space	IBA
cytoplasm	IEA
membrane	IEA
extracellular matrix	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
fibronectin binding	ISS
scavenger receptor activity	ISS
protein binding	IPI	25416956 32296183
laminin binding	ISS
extracellular matrix binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

extracellular matrix binding

laminin binding

cargo receptor activity [inference]

scavenger receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
serine-type endopeptidase activity
zymogen activation

Displaying **all 3** entries
InterPro
SRCR domain
SRCR-like domain superfamily
SRCR-like domain

Ortholog

Displaying entries **1 - 10** of 30 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	232790	ZFIN:ZDB-GENE-060503-479
Danio rerio	245126	ZFIN:ZDB-GENE-060503-479
Mus musculus	269855	ZFIN:ZDB-GENE-060503-479	MOUSE54565
Danio rerio	284297	ZFIN:ZDB-GENE-041210-102
Rattus norvegicus	308341		RATNO15865
Pan troglodytes	456305		PANTR19412
Canis lupus familiaris	611280		CANLF00627
Macaca mulatta	701740		MACMU20305
Equus caballus	100072730		HORSE02084
Callithrix jacchus	100399664		CALJA24014

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements