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cytochrome P450 family 4 subfamily A member 22

Summary

Gene Symbol

CYP4A22

Organism

Homo sapiens (human)

External Links

NCBI Gene

284541

HGNC

20575

KEGG Gene ID

hsa:284541

PubChem

284541

Alliance of Genome Resources

HGNC:20575

Annotation

Keyword

Alternative splicing
Heme
Lipid metabolism
Membrane
Microsome
Monooxygenase
NADP
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q5TCH5
A5PL05
A5PKT5
A0A087WZX9
Q5TCH4	CYPIVA22 Fatty acid omega-hydroxylase Lauric acid omega-hydroxylase Long-chain fatty acid omega-monooxygenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
lauric acid metabolic process	IBA
arachidonic acid metabolic process	IBA
omega-hydroxylase P450 pathway	IDA	10860550
kidney development	IBA
icosanoid biosynthetic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

icosanoid biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

medium-chain fatty acid metabolic process [inference]

lauric acid metabolic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

medium-chain fatty acid metabolic process [inference]

lauric acid metabolic process

lipid modification [inference]

lipid hydroxylation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

medium-chain fatty acid metabolic process [inference]

lauric acid metabolic process

lipid modification [inference]

lipid hydroxylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

icosanoid biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

medium-chain fatty acid metabolic process [inference]

lauric acid metabolic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

icosanoid biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

medium-chain fatty acid metabolic process [inference]

lauric acid metabolic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

medium-chain fatty acid metabolic process [inference]

lauric acid metabolic process

lipid modification [inference]

lipid hydroxylation

olefinic compound metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

icosanoid biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

medium-chain fatty acid metabolic process [inference]

lauric acid metabolic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

omega-hydroxylase P450 pathway

linoleic acid metabolic process

medium-chain fatty acid metabolic process [inference]

lauric acid metabolic process

lipid modification [inference]

lipid hydroxylation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

kidney development

Displaying **all 3** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IBA
endoplasmic reticulum membrane	IEA
extracellular space	IDA	16806293

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
medium-chain fatty acid omega-hydroxylase activity	IDA	10860550
arachidonic acid omega-hydroxylase activity	IDA	10860550
iron ion binding	IEA
long-chain fatty acid omega-hydroxylase activity	IEA
16-hydroxypalmitate dehydrogenase activity	IDA	10860550

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

arachidonic acid monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

fatty acid omega-hydroxylase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

16-hydroxypalmitate dehydrogenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

arachidonic acid monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

fatty acid omega-hydroxylase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K17687

Name

cytochrome P450 family 4 subfamily A11 [EC:1.14.14.1]

References

Rhea

RHEA:40199

O₂ + hexadecanoate

H₂O + H⁺ + 16-hydroxyhexadecanoate

Enzyme

1.14.14.80

PMID

RHEA:41728

O₂ + (9Z)-octadecenoate

H₂O + H⁺ + 18-hydroxy-(9Z)-octadecenoate

Enzyme

1.14.14.80

PMID

RHEA:46356

O₂ + octadecanoate

H₂O + H⁺ + 18-hydroxyoctadecanoate

Enzyme

1.14.14.80

PMID

RHEA:56748

an ω-methyl-long-chain fatty acid + O₂

an ω-hydroxy-long-chain fatty acid + H₂O + H⁺

Enzyme

1.14.14.80

PMID

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080212	polycystic kidney disease 4	DisGeNET
DOID:0110861	autosomal recessive polycystic kidney disease	DisGeNET Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:3571	liver cancer	DisGeNET
DOID:684	hepatocellular carcinoma	DisGeNET

Ortholog

Displaying entries **81 - 82** of 82 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Carlito syrichta	103249750		CARSF15530
Cebus imitator	108312793		CEBIM14851

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements