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SH3 and PX domains 2B

Summary

Gene Symbol

SH3PXD2B

Organism

Homo sapiens (human)

External Links

NCBI Gene

285590

PubChem

285590

Alliance of Genome Resources

HGNC:29242

Annotation

Keyword

Cell junction
Cell projection
Cytoplasm
Differentiation
Disease variant
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH3 domain

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A1X283	Adapter protein HOFI Factor for adipocyte differentiation 49 Tyrosine kinase substrate with four SH3 domains
G3V144

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
eye development	IMP	20137777
heart development	IMP	20137777
superoxide anion generation	IBA
extracellular matrix disassembly	IMP	19755710
superoxide metabolic process	IDA	19755710

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process

superoxide anion generation

cellular process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process

superoxide anion generation

cellular developmental process [inference]

cell differentiation

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

podosome assembly

cellular component disassembly [inference]

extracellular matrix disassembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

podosome assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

podosome assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

podosome assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

connective tissue development [inference]

adipose tissue development

animal organ development [inference]

sensory organ development [inference]

eye development

system development [inference]

skeletal system development

cellular developmental process [inference]

cell differentiation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
anchoring junction	IEA
cell projection	IEA
podosome	ISS
cytoplasm	IBA ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell junction [inference]

anchoring junction

cell projection

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	19755710 20609497
phosphatidylinositol-3,5-bisphosphate binding	ISS
superoxide-generating NADPH oxidase activator activity	IBA
phosphatidylinositol-3-phosphate binding	ISS
phosphatidylinositol-5-phosphate binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding [inference]

SH2 domain binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

superoxide-generating NADPH oxidase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

superoxide-generating NADPH oxidase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SH3

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
SH3 domain
SH3-like domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0111789	Frank-Ter Haar syndrome	Alliance of Genome Resources
DOID:10754	otitis media	Alliance of Genome Resources
DOID:1686	glaucoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	268396		MGI:2442062	MOUSE03877
Rattus norvegicus	303021		RGD:1309926	RATNO01954
Pan troglodytes	471740	9598_0:0018ae		PANTR36831
Canis lupus familiaris	489119			CANLF14814
Xenopus laevis	496321		Xenbase:XB-GENE-1009048
Bos taurus	518356			BOVIN15738
Xenopus tropicalis	549321		Xenbase:XB-GENE-1009043
Danio rerio	553242		ZFIN:ZDB-GENE-060810-52	DANRE21747
Macaca mulatta	702751			MACMU38029
Saccharomyces cerevisiae S288C	852499		SGD:S000000404

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements