GlyCosmos Portal

Submissions

SH3 and PX domains 2B

Summary

Gene Symbol

SH3PXD2B

Organism

Homo sapiens (human)

External Links

NCBI Gene

285590

PubChem

285590

Alliance of Genome Resources

HGNC:29242

JoGo

SH3PXD2B

TogoVar

SH3PXD2B

Annotation

Keyword

Cell junction
Cell projection
Cytoplasm
Differentiation
Disease variant
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH3 domain

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A1X283	Adapter protein HOFI Factor for adipocyte differentiation 49 Tyrosine kinase substrate with four SH3 domains
G3V144

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
skeletal system development	IMP	20137777
eye development	IMP	20137777
superoxide metabolic process	IDA	19755710
heart development	IMP	20137777
extracellular matrix disassembly	IMP	19755710

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process

superoxide anion generation

cellular process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process

superoxide anion generation

cellular developmental process [inference]

cell differentiation

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

podosome assembly

cellular component disassembly [inference]

extracellular matrix disassembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

podosome assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

podosome assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

podosome assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

connective tissue development [inference]

adipose tissue development

animal organ development [inference]

sensory organ development [inference]

eye development

system development [inference]

skeletal system development

cellular developmental process [inference]

cell differentiation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
podosome	ISS
cytoplasm	ISS
cytoplasm	IBA
cell projection	IEA
anchoring junction	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell junction [inference]

anchoring junction

cell projection

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
protein binding	IPI	19755710 20609497
phosphatidylinositol-5-phosphate binding	ISS
superoxide-generating NADPH oxidase activator activity	IBA
phosphatidylinositol-3-phosphate binding	ISS
SH2 domain binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding [inference]

SH2 domain binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

superoxide-generating NADPH oxidase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

superoxide-generating NADPH oxidase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sh3 and px domain-containing

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
phosphatidylinositol binding
superoxide anion generation
superoxide-generating NADPH oxidase activator activity

Displaying **all 8** entries
InterPro
PX domain superfamily
Phox homology
SH3 domain
SH3-like domain superfamily
SH3PXD2B, SH3 domain 1
SH3PXD2B, SH3 domain 2
SH3PXD2B, SH3 domain 3
SH3PXD2B, SH3 domain 4