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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
angiopoietin 2
Summary
- Gene Symbol
-
- ANGPT2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Angiogenesis
- Calcium
- Coiled coil
- Developmental protein
- Differentiation
- Disease variant
- Disulfide bond
- Glycoprotein
- Metal-binding
- Reference proteome
- Secreted
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| O15123 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| Tie signaling pathway | ||
| negative regulation of cell-substrate adhesion | ||
| response to organic cyclic compound | ||
| response to glucose | ||
| positive regulation of angiogenesis |
GO Hierarchy
biological process
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| collagen-containing extracellular matrix | ||
| cell projection | ||
| extracellular region | ||
| extracellular space |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| signaling receptor binding | ||
| metal ion binding | ||
| receptor ligand activity | ||
| receptor tyrosine kinase binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- angiopoietin-2
- Functional Category
-
- E: Amino acid transport and metabolism
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| Tie signaling pathway |
| angiogenesis |
| cell differentiation |
| receptor tyrosine kinase binding |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050580 | hereditary lymphedema | |
| DOID:0050876 | Caroli disease | |
| DOID:0080600 | COVID-19 | |
| DOID:10762 | portal hypertension | |
| DOID:10808 | gastric ulcer | |
| DOID:13025 | retinopathy of prematurity | |
| DOID:1312 | focal segmental glomerulosclerosis | |
| DOID:1574 | alcohol use disorder | |
| DOID:2316 | brain ischemia | |
| DOID:2527 | nephrosis |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 742508 | 9598_0:0025d0 | PANTR41931 | ||
| 5740294 | FB:FBgn0087011 | |||
| 100028850 | MONDO03804 | |||
| 100051890 | HORSE25130 | |||
| 100073414 | ORNAN27748 | |||
| 100225992 | TAEGU20291 | |||
| 100353377 | RABIT14486 | |||
| 100404686 | CALJA09117 | |||
| 100459533 | 9601_0:0022b4 | PONAB34459 | ||
| 100467094 | AILME08543 |
