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hydroxysteroid (17-beta) dehydrogenase 6

Summary

Gene Symbol

Hsd17b6

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

286964

PubChem

286964

Alliance of Genome Resources

RGD:708343

Annotation

Keyword

Glycoprotein
Membrane
Microsome
NAD
Oxidoreductase
Reference proteome
Signal
Steroid metabolism

Proteins

Displaying 1 entry
UniProt	Protein Name
O54753	3-alpha->beta-hydroxysteroid epimerase Oxidative 3-alpha hydroxysteroid dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
steroid metabolic process	IBA
androgen metabolic process	TAS	9188497
retinol metabolic process	IBA
brexanolone catabolic process	ISS
brexanolone catabolic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

ketone catabolic process [inference]

brexanolone catabolic process

small molecule catabolic process [inference]

ketone catabolic process [inference]

brexanolone catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

brexanolone catabolic process

ketone catabolic process [inference]

brexanolone catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

brexanolone catabolic process

organic hydroxy compound catabolic process [inference]

brexanolone catabolic process

hormone metabolic process [inference]

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

ketone catabolic process [inference]

brexanolone catabolic process

brexanolone metabolic process [inference]

brexanolone catabolic process

cellular catabolic process [inference]

ketone catabolic process [inference]

brexanolone catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

steroid catabolic process [inference]

brexanolone catabolic process

androgen metabolic process

brexanolone metabolic process [inference]

brexanolone catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

brexanolone catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular ketone metabolic process [inference]

ketone catabolic process [inference]

brexanolone catabolic process

brexanolone metabolic process [inference]

brexanolone catabolic process

small molecule catabolic process [inference]

ketone catabolic process [inference]

brexanolone catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

steroid catabolic process [inference]

brexanolone catabolic process

androgen metabolic process

brexanolone metabolic process [inference]

brexanolone catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

brexanolone catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular ketone metabolic process [inference]

ketone catabolic process [inference]

brexanolone catabolic process

brexanolone metabolic process [inference]

brexanolone catabolic process

olefinic compound metabolic process [inference]

retinol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

steroid catabolic process [inference]

brexanolone catabolic process

androgen metabolic process

brexanolone metabolic process [inference]

brexanolone catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

brexanolone catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

brexanolone catabolic process

ketone catabolic process [inference]

brexanolone catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

brexanolone catabolic process

organic hydroxy compound catabolic process [inference]

brexanolone catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

brexanolone metabolic process [inference]

brexanolone catabolic process

organic hydroxy compound catabolic process [inference]

brexanolone catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

ketone catabolic process [inference]

brexanolone catabolic process

brexanolone metabolic process [inference]

brexanolone catabolic process

cellular catabolic process [inference]

ketone catabolic process [inference]

brexanolone catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA
membrane	IEA
intracellular membrane-bounded organelle	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
estradiol 17-beta-dehydrogenase [NAD(P)] activity	ISO
estradiol 17-beta-dehydrogenase [NAD(P)] activity	IDA	9188497
NAD-retinol dehydrogenase activity	ISO
NAD-retinol dehydrogenase activity	IBA
oxidoreductase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

estradiol 17-beta-dehydrogenase [NAD(P)] activity

testosterone dehydrogenase [NAD(P)] activity [inference]

testosterone dehydrogenase (NAD+) activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

NAD-retinol dehydrogenase activity

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

estradiol 17-beta-dehydrogenase [NAD(P)] activity

testosterone dehydrogenase [NAD(P)] activity [inference]

testosterone dehydrogenase (NAD+) activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity
steroid metabolic process

Displaying **all 2** entries
InterPro
NAD(P)-binding domain superfamily
Short-chain dehydrogenase/reductase SDR

Ortholog

Displaying entries **1 - 10** of 37 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	622	FB:FBgn0033679
Danio rerio	5959	ZFIN:ZDB-GENE-030912-15
Homo sapiens	8630	Xenbase:XB-GENE-1194363	HUMAN13596
Drosophila melanogaster	15486	FB:FBgn0033679
Mus musculus	27400	Xenbase:XB-GENE-1194363	MOUSE01162
Drosophila melanogaster	71911	FB:FBgn0033679
Drosophila melanogaster	117099	FB:FBgn0033679
Xenopus tropicalis	121214	Xenbase:XB-GENE-1194363
Xenopus tropicalis	286964	Xenbase:XB-GENE-5902365
Macaca mulatta	713549		MACMU05339