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Guidelines

MIRAGE

G protein pathway suppressor 1

Summary

Gene Symbol

GPS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2873

PubChem

2873

Alliance of Genome Resources

HGNC:4549

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Direct protein sequencing
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Signalosome

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A096LP07
C9JFE4
A0A9L9PXT0
Q13098	G protein pathway suppressor 1 JAB1-containing signalosome subunit 1 Protein MFH
A0A096LPJ3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein deneddylation	IDA	19141280
JNK cascade	TAS	8943324
protein neddylation	NAS	24421388
regulation of protein neddylation	NAS	24421388

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein neddylation

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein neddylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein neddylation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	IDA	24421388
nucleoplasm	TAS
nucleoplasm	IDA
cytoplasm	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

COP9 signalosome

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
GTPase inhibitor activity	TAS	8943324
protein binding	IPI	17337451 18850735 19444310 19615732 20399188 21145461 24421388 25043011 27029275 32296183 33961781

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

GTPase inhibitor activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

GTPase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Signalosome subunit 1

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
26S proteasome regulatory subunit Rpn7, N-terminal
26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1
Proteasome component (PCI) domain
Winged helix DNA-binding domain superfamily

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	2873	Xenbase:XB-GENE-955148
Rattus norvegicus	117039		RATNO03356
Mus musculus	209318		MOUSE05287
Bos taurus	525572		BOVIN13733
Macaca mulatta	719343		MACMU13898
Pan troglodytes	747173		PANTR15733
Monodelphis domestica	100025216		MONDO10895
Pongo abelii	100173885		PONAB11319
Ciona intestinalis	100176942		CIOIN05951
Taeniopygia guttata	100232676		TAEGU07252

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Last updated: December 8, 2025