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G protein pathway suppressor 1

Summary

Gene Symbol

GPS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2873

PubChem

2873

Alliance of Genome Resources

HGNC:4549

JoGo

GPS1

TogoVar

GPS1

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Direct protein sequencing
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Signalosome

Proteins

Displaying **all 8** entries
UniProt	Protein Name
A0A096LPJ3	G protein pathway suppressor 1 JAB1-containing signalosome subunit 1
A0A9L9PXT0	G protein pathway suppressor 1 JAB1-containing signalosome subunit 1
A0A096LP07	G protein pathway suppressor 1 JAB1-containing signalosome subunit 1
A0ABJ7H8D6
Q13098	G protein pathway suppressor 1 JAB1-containing signalosome subunit 1 Protein MFH
A8K070	G protein pathway suppressor 1 JAB1-containing signalosome subunit 1
C9JFE4	G protein pathway suppressor 1 JAB1-containing signalosome subunit 1
A0A9L9PX62	G protein pathway suppressor 1 JAB1-containing signalosome subunit 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein deneddylation	IDA	19141280
JNK cascade	TAS	8943324
protein neddylation	NAS	24421388
regulation of protein neddylation	NAS	24421388

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein neddylation

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein neddylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein neddylation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	IDA	24421388
nucleoplasm	TAS
nucleoplasm	IDA
cytoplasm	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

COP9 signalosome

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
GTPase inhibitor activity	TAS	8943324
protein binding	IPI	17337451 18850735 19444310 19615732 20399188 21145461 24421388 25043011 27029275 32296183 33961781

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

GTPase inhibitor activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

GTPase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Signalosome subunit 1

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
26S proteasome regulatory subunit Rpn7, N-terminal
26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1
Proteasome component (PCI) domain
Winged helix DNA-binding domain superfamily