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glutathione peroxidase 3
Summary
- Gene Symbol
-
- GPX3
- Aliases
-
- selenoprotein GPX3
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Direct protein sequencing
- Peroxidase
- Reference proteome
- Secreted
- Selenocysteine
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| P22352 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to lipid hydroperoxide | ||
| hydrogen peroxide catabolic process | ||
| hydrogen peroxide catabolic process | ||
| cellular oxidant detoxification |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| extracellular space | ||
| extracellular exosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| glutathione peroxidase activity | ||
| glutathione peroxidase activity | ||
| protein binding | ||
| selenium binding | ||
| selenium binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Glutathione peroxidase
- Functional Category
-
- E: Amino acid transport and metabolism
- I: Lipid transport and metabolism
- V: Defense mechanisms
| Gene Ontology |
|---|
| cellular oxidant detoxification |
| oxidoreductase activity |
| response to oxidative stress |
| InterPro |
|---|
| Glutathione peroxidase conserved site |
| Glutathione peroxidase |
| Thioredoxin-like superfamily |
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10534 | stomach cancer | |
| DOID:10763 | hypertension | |
| DOID:1682 | congenital heart disease | |
| DOID:1993 | rectum cancer | |
| DOID:3526 | cerebral infarction | |
| DOID:3748 | esophagus squamous cell carcinoma | |
| DOID:4914 | esophagus adenocarcinoma | |
| DOID:5041 | esophageal cancer | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:7941 | Barrett's adenocarcinoma |
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP001191
- Gene Name
- glutathione peroxidase 3 (plasma)
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 2876 | WB:WBGene00007516 | ||
| 2877 | WB:WBGene00007516 | ||
| 2878 | Xenbase:XB-GENE-5884491 | ||
| 2880 | Xenbase:XB-GENE-5884491 | ||
| 14775 | WB:WBGene00007516 | ||
| 14778 | MOUSE05707 | ||
| 181178 | Xenbase:XB-GENE-5884491 | ||
| 182513 | Xenbase:XB-GENE-5884491 | ||
| 257202 | Xenbase:XB-GENE-5884491 | ||
| 281210 | BOVIN33771 |
