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growth factor receptor bound protein 10

Summary

Gene Symbol

GRB10

Organism

Homo sapiens (human)

External Links

NCBI Gene

2887

PubChem

2887

Alliance of Genome Resources

HGNC:4564

JoGo

GRB10

TogoVar

GRB10

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Direct protein sequencing
Phosphoprotein
Proteomics identification
Reference proteome
SH2 domain

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A2R8YCL1
Q13322	GRB10 adapter protein Insulin receptor-binding protein Grb-IR

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
insulin receptor signaling pathway	ISS
insulin receptor signaling pathway	IBA
gene expression	IEA
negative regulation of Wnt signaling pathway	IDA	17376403
negative regulation of Wnt signaling pathway	IBA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cell motility [inference]

cell migration [inference]

muscle cell migration [inference]

smooth muscle cell migration [inference]

vascular associated smooth muscle cell migration

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of cold-induced thermogenesis

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

regulation of generation of precursor metabolites and energy [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

positive regulation of phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

regulation of polysaccharide metabolic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

regulation of glycogen metabolic process [inference]

regulation of glycogen biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of polysaccharide metabolic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

regulation of glycogen metabolic process [inference]

regulation of glycogen biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of signal transduction [inference]

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of vascular endothelial growth factor receptor signaling pathway [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

regulation of glucose import [inference]

negative regulation of glucose import

negative regulation of transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of cold-induced thermogenesis

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of signal transduction [inference]

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of vascular endothelial growth factor receptor signaling pathway [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of vascular endothelial growth factor receptor signaling pathway [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of signal transduction [inference]

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of vascular endothelial growth factor receptor signaling pathway [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

regulation of generation of precursor metabolites and energy [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

positive regulation of phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

regulation of glucose import [inference]

negative regulation of glucose import

negative regulation of transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of glycogen metabolic process [inference]

negative regulation of glycogen biosynthetic process

negative regulation of transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytoplasm	TAS	9006901
cytosol	TAS
plasma membrane	TAS	9006901
protein-containing complex	IDA	20878056

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
insulin receptor binding	ISS	15664450
insulin receptor binding	IBA
protein binding	IPI	15060076 15722337 20670374 20878056 23246379 24658140 25814554 31980649 32296183 32814053 35271311 36931259 8798570 9506989
signaling receptor complex adaptor activity	IEA
identical protein binding	IPI	19648926 32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

insulin receptor binding

identical protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

signaling receptor complex adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

growth factor receptor-bound

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
insulin receptor signaling pathway
negative regulation of insulin receptor signaling pathway

Displaying **all 9** entries
InterPro
APBB1IP, PH domain
BPS (Between PH and SH2) domain
GRB/APBB1IP
PH-like domain superfamily
Pleckstrin homology domain
Ras-associating domain
SH2 domain superfamily
SH2 domain
Ubiquitin-like domain superfamily

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements