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FIC domain protein adenylyltransferase

Summary

Gene Symbol

Ficd

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

288741

PubChem

288741

Alliance of Genome Resources

RGD:1359391

Annotation

Keyword

ATP-binding
Endoplasmic reticulum
Glycoprotein
Hydrolase
Magnesium
Manganese
Membrane
Nucleotidyltransferase
Phosphoprotein
Reference proteome
Repeat
Signal-anchor
TPR repeat
Transmembrane helix
Unfolded protein response

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6AY47	AMPylator FICD De-AMPylase FICD FIC domain-containing protein
A6J228	AMPylator FICD FIC domain-containing protein

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
response to unfolded protein	IEA
protein adenylylation	ISS
protein adenylylation	ISO
response to endoplasmic reticulum stress	ISS
response to endoplasmic reticulum stress	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

protein denucleotidylation [inference]

protein deadenylylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

protein denucleotidylation [inference]

protein deadenylylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

protein denucleotidylation [inference]

protein deadenylylation

macromolecule modification [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

protein denucleotidylation [inference]

protein deadenylylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

protein denucleotidylation [inference]

protein deadenylylation

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	ISS
endoplasmic reticulum	ISO
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	ISO
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

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GO Term	Evidence Code	PMID
ATP binding	ISS
ATP binding	ISO
ATP binding	IEA
Hsp70 protein binding	ISO
Hsp70 protein binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

adenylyltransferase activity [inference]

AMPylase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

protein adenylylhydrolase activity

catalytic activity, acting on a protein [inference]

protein adenylylhydrolase activity

binding [inference]

protein binding [inference]

heat shock protein binding [inference]

Hsp70 protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

protein-folding chaperone binding

Hsp70 protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Adenosine monophosphate-protein transferase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
AMPylase activity
ATP binding
nucleotide binding
transferase activity

Displaying **all 3** entries
InterPro
Fido domain-containing protein
Fido domain
Fido-like domain superfamily

Rhea

RHEA:58120

ATP

diphosphate

Enzyme

2.7.7.108

PMID

30270044

RHEA:54288

ATP

diphosphate

Enzyme

2.7.7.108

PMID

RHEA:54292

ATP

diphosphate

Enzyme

2.7.7.108

PMID

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	11153	Xenbase:XB-GENE-992753	HUMAN15194
Mus musculus	231630	Xenbase:XB-GENE-992753	MOUSE44982
Xenopus tropicalis	288741	Xenbase:XB-GENE-992753
Danio rerio	334648		DANRE36816
Bos taurus	505923		BOVIN09714
Macaca mulatta	706780		MACMU02940
Pan troglodytes	743566		PANTR06806
Monodelphis domestica	100025324		MONDO18677
Equus caballus	100059882		HORSE41743
Ornithorhynchus anatinus	100076324		ORNAN14144

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements