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glutamate ionotropic receptor delta type subunit 2

Summary

Gene Symbol

GRID2

Organism

Homo sapiens (human)

External Links

NCBI Gene

2895

PubChem

2895

Alliance of Genome Resources

HGNC:4576

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Neurodegeneration
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O43424

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS
glutamate receptor signaling pathway	TAS	9465309
protein localization	ISS
regulation of neuron projection development	IEA
cerebellar granule cell differentiation	ISS

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

synaptic signaling via neuropeptide

cell adhesion [inference]

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation in hindbrain [inference]

cerebellar granule cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar granule cell differentiation

glutamatergic neuron differentiation [inference]

cerebellar granule cell differentiation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

transmembrane transport [inference]

monoatomic ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly [inference]

excitatory synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

excitatory synapse assembly

synapse organization [inference]

synapse assembly [inference]

excitatory synapse assembly

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation in hindbrain [inference]

cerebellar granule cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar granule cell differentiation

glutamatergic neuron differentiation [inference]

cerebellar granule cell differentiation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity [inference]

regulation of long-term synaptic depression [inference]

positive regulation of long-term synaptic depression

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

synaptic signaling via neuropeptide

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of long-term synaptic depression

negative regulation of biological process [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity [inference]

regulation of long-term synaptic depression [inference]

positive regulation of long-term synaptic depression

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of neuron apoptotic process

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

regulation of excitatory synapse assembly [inference]

regulation of postsynaptic density assembly

regulation of presynapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of organelle assembly [inference]

regulation of postsynaptic specialization assembly [inference]

regulation of postsynaptic density assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development

regulation of organelle organization [inference]

regulation of organelle assembly [inference]

regulation of postsynaptic specialization assembly [inference]

regulation of postsynaptic density assembly

regulation of postsynaptic density organization [inference]

regulation of postsynaptic density assembly

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

regulation of excitatory synapse assembly [inference]

regulation of postsynaptic density assembly

regulation of presynapse assembly

regulation of presynapse organization [inference]

regulation of presynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynaptic density organization [inference]

regulation of postsynaptic density assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

regulation of excitatory synapse assembly [inference]

regulation of postsynaptic density assembly

regulation of presynapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

regulation of synaptic plasticity [inference]

regulation of long-term synaptic depression [inference]

positive regulation of long-term synaptic depression

regulation of postsynaptic membrane neurotransmitter receptor levels

Displaying entries **11 - 12** of 12 in total

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GO Term	Evidence Code	PMID
postsynaptic density membrane	IBA
glutamatergic synapse	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

AMPA glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

AMPA glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

AMPA glutamate receptor complex

trans-synaptic protein complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

AMPA glutamate receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

excitatory synapse [inference]

parallel fiber to Purkinje cell synapse

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
AMPA glutamate receptor activity	IBA
protein binding	IPI	27418511
glutamate receptor activity	TAS	9465309
PDZ domain binding	ISS
identical protein binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity [inference]

AMPA glutamate receptor activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity [inference]

AMPA glutamate receptor activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

AMPA glutamate receptor activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

amide transmembrane transporter activity [inference]

glutamate-gated receptor activity [inference]

AMPA glutamate receptor activity

salt transmembrane transporter activity [inference]

glutamate-gated receptor activity [inference]

AMPA glutamate receptor activity

binding [inference]

protein binding

protein domain specific binding [inference]

PDZ domain binding

ion binding [inference]

cation binding [inference]

metal ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

glutamate receptor activity

glutamate-gated receptor activity [inference]

AMPA glutamate receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glutamate receptor ionotropic, delta-2

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
glutamate receptor activity
ligand-gated monoatomic ion channel activity
modulation of chemical synaptic transmission
monoatomic ion channel activity
monoatomic ion transport
synaptic transmission, glutamatergic
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Displaying **all 6** entries
InterPro
Ionotropic glutamate receptor, C-terminal
Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Ionotropic glutamate receptor, metazoa
Ionotropic glutamate receptor
Periplasmic binding protein-like I
Receptor, ligand binding region

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080042	autosomal recessive spinocerebellar ataxia 18	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	2894	FB:FBgn0052704
Xenopus tropicalis	2895	Xenbase:XB-GENE-955038
Drosophila melanogaster	14803	FB:FBgn0052704
Mus musculus	14804	Xenbase:XB-GENE-955038	MOUSE49768
Xenopus tropicalis	33683	Xenbase:XB-GENE-955038
Drosophila melanogaster	79219	FB:FBgn0052704
Rattus norvegicus	79220	Xenbase:XB-GENE-955038	RATNO31632
Danio rerio	448841	Xenbase:XB-GENE-955038	DANRE42510
Canis lupus familiaris	487863		CANLF13076
Macaca mulatta	704787		MACMU36396

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Acknowledgements