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mono-ADP ribosylhydrolase 1

Summary

Gene Symbol

MACROD1

Aliases

LRP16

Organism

Homo sapiens (human)

External Links

NCBI Gene

28992

HGNC

29598

PubChem

28992

Alliance of Genome Resources

HGNC:29598

Annotation

Keyword

3D-structure
Acetylation
Chromosomal rearrangement
DNA damage
Hydrolase
Isopeptide bond
Nucleus
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BQ69	MACRO domain-containing protein 1 O-acetyl-ADP-ribose deacetylase MACROD1 Protein LRP16 [Protein ADP-ribosylaspartate] hydrolase MACROD1 [Protein ADP-ribosylglutamate] hydrolase MACROD1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
purine nucleoside metabolic process	IBA IDA	21257746
peptidyl-glutamate ADP-deribosylation	IBA IDA	23474714
cellular response to DNA damage stimulus	IBA IMP	23474712
protein de-ADP-ribosylation	IDA	23474712
DNA damage response	IBA IMP	23474712

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

macromolecule modification [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleus	IDA	23474712
nucleoplasm	IBA IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
hydrolase activity, acting on glycosyl bonds	IDA	23474712
ADP-ribosylglutamate hydrolase activity	IBA IDA	23474714
protein binding	IPI	17914104 20035625 21483817 32296183
deacetylase activity	IDA	21257746

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

ADP-ribosylglutamate hydrolase activity

deacetylase activity

catalytic activity, acting on a protein [inference]

ADP-ribosylglutamate hydrolase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:59244

3''-O-acetyl-ADP-D-ribose + H₂O

H⁺ + acetate + ADP-D-ribose

Enzyme

3.1.1.106

PMID

RHEA:57060

H₂O + 2''-O-acetyl-ADP-D-ribose

H⁺ + acetate + ADP-D-ribose

Enzyme

3.1.1.106

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 29 in total

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DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	DisGeNET
DOID:0050742	nicotine dependence	DisGeNET
DOID:0060597	atypical chronic myeloid leukemia, BCR-ABL1 negative	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:1037	lymphoid leukemia	DisGeNET
DOID:114	heart disease	DisGeNET
DOID:1240	leukemia	DisGeNET
DOID:1287	cardiovascular system disease	DisGeNET
DOID:13189	gout	DisGeNET DisGeNET
DOID:1380	endometrial cancer	DisGeNET DisGeNET

Ortholog

Displaying entries **1 - 10** of 44 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178044	WB:WBGene00007106
Danio rerio	447834	ZFIN:ZDB-GENE-040912-100	DANRE07508
Ictalurus punctatus	108269168		ICTPU34154
Salmo trutta	115168660		SALTR43172
Oreochromis niloticus	100703609		ORENI47062
Sparus aurata	115568587		SPAAU64710
Xenopus laevis	100381041	Xenbase:XB-GENE-6252561
Xenopus laevis	108715149	Xenbase:XB-GENE-17346443
Xenopus tropicalis	496629	Xenbase:XB-GENE-947080
Chrysemys picta bellii	101946621		CHRPI08892

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Acknowledgements