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ABR activator of RhoGEF and GTPase

Summary

Gene Symbol

ABR

Organism

Homo sapiens (human)

External Links

NCBI Gene

29

PubChem

29

Alliance of Genome Resources

HGNC:81

Annotation

Keyword

Alternative splicing
Cell projection
Coiled coil
GTPase activation
Guanine-nucleotide releasing factor
Phosphoprotein
Proteomics identification
Reference proteome
Synapse

Proteins

Displaying **all 6** entries
UniProt	Protein Name
B7Z683
B7Z7Z1
Q12979
I3L4Y1
Q6ZT60
B7Z2X0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
small GTPase mediated signal transduction	TAS	8262969
modulation of chemical synaptic transmission	ISS
regulation of small GTPase mediated signal transduction	TAS
activation of GTPase activity	IDA	7479768

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
membrane	IBA
membrane	HDA	19946888
axon	IEA
dendritic spine	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

neuron spine [inference]

dendritic spine

postsynapse [inference]

dendritic spine

Displaying **all 5** entries
GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	TAS
guanyl-nucleotide exchange factor activity	IDA	7479768
GTPase activator activity	TAS
GTPase activator activity	IDA	7479768
protein binding	IPI	20962234

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Active breakpoint cluster region-related protein

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 10** entries
InterPro
Abr/Bcr
C2 domain superfamily
C2 domain
Dbl homology (DH) domain superfamily
Dbl homology (DH) domain
Guanine-nucleotide dissociation stimulator, CDC24, conserved site
PH-like domain superfamily
Pleckstrin homology domain
Rho GTPase activation protein
Rho GTPase-activating protein domain