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glutamate metabotropic receptor 5

Summary

Gene Symbol

GRM5

Organism

Homo sapiens (human)

External Links

NCBI Gene

2915

PubChem

2915

Alliance of Genome Resources

HGNC:4597

JoGo

GRM5

TogoVar

GRM5

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Methylation
Phosphoprotein
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8K5P7
P41594

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 23 in total

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GO Term	Evidence Code	PMID
learning	IEA
locomotory behavior	IEA
positive regulation of MAPK cascade	IEA
positive regulation of long-term neuronal synaptic plasticity	IEA
synapse organization	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

trans-synaptic signaling by lipid [inference]

trans-synaptic signaling by endocannabinoid [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

trans-synaptic signaling, modulating synaptic transmission [inference]

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition

learning or memory

learning

behavior [inference]

learning or memory

learning

locomotory behavior

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to oxygen-containing compound [inference]

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

adaptation of signaling pathway [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of synaptic transmission, glutamatergic

trans-synaptic signaling, modulating synaptic transmission [inference]

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

trans-synaptic signaling by lipid [inference]

trans-synaptic signaling by endocannabinoid [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

trans-synaptic signaling, modulating synaptic transmission [inference]

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

adaptation of signaling pathway [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

adaptation of signaling pathway [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of synaptic transmission, glutamatergic

trans-synaptic signaling, modulating synaptic transmission [inference]

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity [inference]

positive regulation of long-term neuronal synaptic plasticity

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
plasma membrane	TAS
plasma membrane	IMP	7908515
plasma membrane	IBA
dendrite	IDA	24012003

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

neuron spine [inference]

dendritic spine

glial cell projection [inference]

astrocyte projection

dendritic shaft

cell body [inference]

neuronal cell body

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA
G protein-coupled receptor activity	IMP	7908515
protein binding	IPI	19694902 28130356
glutamate receptor activity	IDA	7908515
protein tyrosine kinase activator activity	IDA	24012003