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dynactin subunit 1

Summary

Gene Symbol

Dctn1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29167

PubChem

29167

Alliance of Genome Resources

RGD:62038

Annotation

Keyword

3D-structure
Coiled coil
Cytoskeleton
Dynein
Microtubule
Mitosis
Nucleus
Phosphoprotein
Reference proteome
Transport
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P28023	150 kDa dynein-associated polypeptide DAP-150 p150-glued

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 48 in total

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GO Term	Evidence Code	PMID
neuromuscular junction development	ISO
neuromuscular junction development	IEA
biological_process	ND
centriole-centriole cohesion	ISS
centriole-centriole cohesion	ISO

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

cytoplasmic microtubule organization

microtubule anchoring [inference]

microtubule anchoring at microtubule organizing center [inference]

microtubule anchoring at centrosome

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cell cycle process [inference]

centriole-centriole cohesion

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

cell division

cellular localization [inference]

intracellular transport [inference]

nuclear migration

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

cytoplasmic microtubule organization

microtubule anchoring [inference]

microtubule anchoring at microtubule organizing center [inference]

microtubule anchoring at centrosome

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

cilium organization [inference]

cilium assembly [inference]

non-motile cilium assembly

organelle assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

cellular component disassembly [inference]

membrane disassembly [inference]

nuclear membrane disassembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

organelle assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly [inference]

non-motile cilium assembly

neuron projection organization [inference]

neuron projection maintenance

plasma membrane bounded cell projection assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

membrane organization [inference]

membrane disassembly [inference]

nuclear membrane disassembly

nuclear membrane organization [inference]

nuclear membrane disassembly

supramolecular fiber organization [inference]

cytoplasmic microtubule organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process

behavior [inference]

motor behavior

developmental process [inference]

anatomical structure development [inference]

ventral spinal cord development

homeostatic process [inference]

cellular homeostasis [inference]

neuron cellular homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

intracellular transport [inference]

nuclear migration

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport

pigment granule transport [inference]

melanosome transport

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear migration

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

establishment of melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

establishment of organelle localization [inference]

nuclear migration

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

establishment of melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

organelle localization [inference]

nucleus localization [inference]

nuclear migration

vesicle localization [inference]

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

establishment of melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

pigment granule localization [inference]

melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of organelle localization [inference]

nuclear migration

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

establishment of melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

cellular localization [inference]

intracellular transport [inference]

nuclear migration

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of neuromuscular junction development

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of spindle organization [inference]

regulation of mitotic spindle organization

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of neuromuscular junction development

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of cytoskeleton organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of spindle organization [inference]

regulation of mitotic spindle organization

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of synapse organization [inference]

regulation of neuromuscular junction development [inference]

positive regulation of neuromuscular junction development

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of neuromuscular junction development

regulation of supramolecular fiber organization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of spindle organization [inference]

regulation of mitotic spindle organization

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

Displaying entries **1 - 5** of 56 in total

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GO Term	Evidence Code	PMID
kinetochore	ISS
kinetochore	ISO
kinetochore	IBA
kinetochore	IEA
spindle pole	ISO

GO Hierarchy

cellular component

protein-containing complex

microtubule associated complex

dynein complex

cytoplasmic dynein complex

membrane protein complex [inference]

retromer complex

intracellular protein-containing complex [inference]

centriolar subdistal appendage

catalytic complex [inference]

dynein complex

cytoplasmic dynein complex

cellular anatomical entity [inference]

spindle pole

cytoplasm

cell cortex

cell cortex region

cytoplasmic region [inference]

cell cortex region

microtubule organizing center [inference]

envelope [inference]

organelle envelope [inference]

nuclear envelope

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

neuron projection

axon

organelle [inference]

membrane-bounded organelle [inference]

cilium

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

cell body [inference]

neuronal cell body

intercellular bridge

supramolecular complex [inference]

kinetochore

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

microtubule end [inference]

microtubule plus-end

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
microtubule binding	ISO
microtubule binding	IDA	7878030
microtubule binding	IEA
tubulin binding	ISS
tubulin binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding

microtubule binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dynactin subunit 1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cytoplasmic microtubule organization
microtubule plus-end binding

Displaying **all 3** entries
InterPro
CAP Gly-rich domain superfamily
CAP Gly-rich domain
Dynein associated protein

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cytoplasmic dynein complex	PMID:1828535

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1639	Xenbase:XB-GENE-5933522	HUMAN63332
Mus musculus	13191	Xenbase:XB-GENE-5933522	MOUSE50919
Xenopus tropicalis	29167	Xenbase:XB-GENE-5933522
Pan troglodytes	459332		PANTR27947
Canis lupus familiaris	483106		CANLF05224
Bos taurus	511045		BOVIN02108
Macaca mulatta	708290		MACMU08236
Danio rerio	100003026		DANRE06232
Monodelphis domestica	100017556		MONDO26179
Pongo abelii	100174308		PONAB23439

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements