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Guidelines

MIRAGE

calsequestrin 2

Summary

Gene Symbol

Casq2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29209

KEGG Gene ID

PubChem

29209

Alliance of Genome Resources

RGD:2276

Annotation

Keyword

Calcium
Direct protein sequencing
Glycoprotein
Metal-binding
Muscle protein
Phosphoprotein
Reference proteome
Sarcoplasmic reticulum
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P51868	Calsequestrin, cardiac muscle isoform

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
regulation of heart rate	ISO
intracellular calcium ion homeostasis	ISO
biological_process	ND
regulation of cell communication by electrical coupling	ISO
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

cardiac muscle contraction

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

response to stimulus [inference]

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

response to nitrogen compound [inference]

response to purine-containing compound [inference]

response to caffeine [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to alkaloid [inference]

response to caffeine [inference]

cellular response to caffeine

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

negative regulation of potassium ion transport

regulation of calcium ion transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

negative regulation of monoatomic ion transport [inference]

negative regulation of potassium ion transport

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of potassium ion transport

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of potassium ion transport

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of cell communication [inference]

regulation of cell communication by electrical coupling

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of cardiac muscle cell contraction

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of cardiac muscle cell contraction

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of cardiac muscle cell contraction

regulation of membrane repolarization

regulation of membrane repolarization during action potential [inference]

regulation of membrane repolarization during cardiac muscle cell action potential [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of ventricular cardiac muscle cell membrane repolarization [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of membrane repolarization during cardiac muscle cell action potential [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of action potential [inference]

regulation of membrane repolarization during action potential [inference]

regulation of membrane repolarization during cardiac muscle cell action potential [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of biological quality [inference]

regulation of heart rate

regulation of membrane potential [inference]

regulation of membrane repolarization

regulation of membrane repolarization during action potential [inference]

regulation of membrane repolarization during cardiac muscle cell action potential [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of ventricular cardiac muscle cell membrane repolarization [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of membrane repolarization during cardiac muscle cell action potential [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of action potential [inference]

regulation of membrane repolarization during action potential [inference]

regulation of membrane repolarization during cardiac muscle cell action potential [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISO
sarcoplasmic reticulum	ISO
sarcoplasmic reticulum	IDA
sarcoplasmic reticulum	IEA
Z disc	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

junctional membrane complex

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen [inference]

sarcoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein kinase C binding	IDA
calcium ion binding	ISO
calcium ion binding	IBA
calcium ion binding	IEA
protein homodimerization activity	IDA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein kinase C binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

calcium-dependent protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular sequestering activity [inference]

metal ion sequestering activity [inference]

calcium ion sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
sarcoplasmic reticulum	PMID:17569730

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	845	HGNC:1513
Mus musculus	12373	MGI:1309469
Caenorhabditis elegans	181563	WB:WBGene00000822

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026