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troponin I3, cardiac type

Summary

Gene Symbol

Tnni3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29248

PubChem

29248

Alliance of Genome Resources

RGD:62052

Annotation

Keyword

Acetylation
Actin-binding
Muscle protein
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P23693	Cardiac troponin I

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
vasculogenesis	ISO
regulation of systemic arterial blood pressure by ischemic conditions	ISO
skeletal muscle contraction	IBA
intracellular calcium ion homeostasis	ISO
regulation of muscle contraction	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction

circulatory system process [inference]

heart process [inference]

heart contraction

nervous system process [inference]

nervous system process involved in regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure by ischemic conditions

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

muscle tissue morphogenesis [inference]

cardiac muscle tissue morphogenesis [inference]

ventricular cardiac muscle tissue morphogenesis

anatomical structure development [inference]

animal organ development [inference]

heart development

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction

regulation of smooth muscle contraction

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of molecular function [inference]

regulation of ATP-dependent activity [inference]

negative regulation of ATP-dependent activity

negative regulation of molecular function [inference]

negative regulation of ATP-dependent activity

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	15601779
troponin complex	ISO
troponin complex	TAS	1886137
troponin complex	IBA
troponin complex	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

troponin complex

cardiac Troponin complex

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

contractile fiber

myofibril

cardiac myofibril

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

contractile fiber

myofibril

cardiac myofibril

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber

myofibril

cardiac myofibril

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
actin binding	ISO
actin binding	IEA
protein binding	IPI	21569246
calcium channel inhibitor activity	ISO
protein kinase binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein-containing complex binding [inference]

actin filament binding

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

ion channel regulator activity [inference]

calcium channel regulator activity [inference]

calcium channel inhibitor activity

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Troponin

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
actin binding
cardiac muscle contraction
skeletal muscle contraction

Displaying **all 2** entries
InterPro
Troponin domain superfamily
Troponin

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
myofibril	PMID:11448842
contractile muscle fiber	PMID:9409484

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7137	Xenbase:XB-GENE-486987	HUMAN46130
Mus musculus	21954	Xenbase:XB-GENE-486987	MOUSE54212
Xenopus tropicalis	29248	Xenbase:XB-GENE-486987
Canis lupus familiaris	403566		CANLF00647
Equus caballus	100034065		HORSE01995
Sus scrofa	100049696		PIGXX28568
Ornithorhynchus anatinus	100077614		ORNAN01484
Callithrix jacchus	100389415		CALJA23789
Pongo abelii	100446190		PONAB15127
Nomascus leucogenys	100590739		NOMLE01892