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serpin family H member 1

Summary

Gene Symbol

Serpinh1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29345

PubChem

29345

Alliance of Genome Resources

RGD:69302

Annotation

Keyword

Acetylation
Chaperone
Direct protein sequencing
Endoplasmic reticulum
Glycoprotein
Phosphoprotein
Proteomics identification
Reference proteome
Signal
Stress response

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P29457	47 kDa heat shock protein Collagen-binding protein GP46
A6I6G9	Collagen-binding protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
protein maturation	ISO
response to vitamin D	IEP	32585450

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation

biosynthetic process [inference]

collagen biosynthetic process

collagen metabolic process [inference]

collagen biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis

cellular developmental process [inference]

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to organic substance [inference]

response to organic cyclic compound

response to vitamin D

response to lipid [inference]

response to vitamin D

response to oxygen-containing compound [inference]

response to vitamin D

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	IEA
membrane raft	ISO
endoplasmic reticulum	IBA IEA ISO
endoplasmic reticulum-Golgi intermediate compartment	ISO
extracellular space	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

membrane microdomain [inference]

membrane raft

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase inhibitor activity	IBA IEA
collagen binding	IEA TAS	1654327
unfolded protein binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

unfolded protein binding

protein-containing complex binding [inference]

collagen binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

serpin H1

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
collagen binding
collagen fibril organization
serine-type endopeptidase inhibitor activity

Displaying **all 7** entries
InterPro
Serpin H1, serpin domain
Serpin domain
Serpin family
Serpin superfamily, domain 1
Serpin superfamily, domain 2
Serpin superfamily
Serpin, conserved site

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110346	osteogenesis imperfecta type 10	Alliance of Genome Resources
DOID:0111144	preterm premature rupture of the membranes	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 90** of **139** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rhinopithecus bieti	108537625			RHIBE24664
Cyprinus carpio carpio	109059226			CYPCA92944
Cyprinus carpio carpio	109097437			CYPCA131173
Cyprinus carpio carpio	109103942			CYPCA114986
Crocodylus porosus	109306883			CROPO03970
Castor canadensis	109680763	51338_0:00092a
Phascolarctos cinereus	110210564			PHACI00726
Mus caroli	110297602	10089_0:001d54
Mus pahari	110316966	10093_0:0004f2
Meriones unguiculatus	110560407	10047_0:003634

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024