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adrenoceptor alpha 1D

Summary

Gene Symbol

Adra1d

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29413

PubChem

29413

Alliance of Genome Resources

RGD:62064

Annotation

Keyword

Cell membrane
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P23944	Alpha-1A adrenergic receptor Alpha-1D adrenoreceptor RA42

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure	ISO
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	ISO
phospholipase C-activating G protein-coupled receptor signaling pathway	IBA
positive regulation of cytosolic calcium ion concentration	IBA
cell-cell signaling	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

neuron-glial cell signaling

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

adrenergic receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

vasoconstriction [inference]

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

signaling [inference]

cell-cell signaling

neuron-glial cell signaling

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

adrenergic receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

negative regulation of heart contraction [inference]

negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

negative regulation of multicellular organismal process [inference]

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

vasoconstriction [inference]

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
alpha1-adrenergic receptor activity	ISO
alpha1-adrenergic receptor activity	IDA	11171057
alpha1-adrenergic receptor activity	IBA
alpha1-adrenergic receptor activity	IEA
identical protein binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

identical protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

adrenergic receptor activity [inference]

alpha-adrenergic receptor activity [inference]

alpha1-adrenergic receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5-hydroxytryptamine receptor

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway
alpha1-adrenergic receptor activity
cell-cell signaling
phospholipase C-activating G protein-coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **11 - 20** of 44 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	184572	ZFIN:ZDB-GENE-090312-203
Bos taurus	539543		BOVIN04714
Monodelphis domestica	100030860		MONDO07055
Equus caballus	100066003		HORSE21261
Ovis aries	100170316		SHEEP04370
Callithrix jacchus	100397860		CALJA35521
Macaca mulatta	100430996		MACMU01912
Pongo abelii	100461963		PONAB20345
Cavia porcellus	100735770		CAVPO04755
Otolemur garnettii	100960577		OTOGA13411