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G protein-coupled receptor, class C, group 6, member A

Summary

Gene Symbol

Gprc6a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

294394

PubChem

294394

Alliance of Genome Resources

RGD:735077

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6K472
Q70VB1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	IEA
adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
calcium-mediated signaling	IEA
positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

response to stimulus [inference]

response to chemical [inference]

response to acid chemical [inference]

response to amino acid

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amino acid

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amino acid

response to oxygen-containing compound [inference]

response to amino acid

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of testosterone biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of testosterone biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of testosterone biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of testosterone biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of testosterone biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of testosterone biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of testosterone biosynthetic process

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of testosterone biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of testosterone biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IDA	17478059
plasma membrane	IBA
plasma membrane	IEA
cell surface	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor activity	ISS
G protein-coupled receptor activity	ISO
G protein-coupled receptor activity	IBA
G protein-coupled receptor activity	IEA
G protein-coupled peptide receptor activity	ISO

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled peptide receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

metabotropic glutamate receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
InterPro
GPCR family 3, C-terminal
GPCR, family 3, extracellular calcium-sensing receptor-related
GPCR, family 3, nine cysteines domain superfamily
GPCR, family 3, nine cysteines domain
GPCR, family 3
Periplasmic binding protein-like I
Receptor, ligand binding region

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	210198	Xenbase:XB-GENE-991397	MOUSE00946
Homo sapiens	222545	Xenbase:XB-GENE-991397	HUMAN86260
Xenopus tropicalis	294394	Xenbase:XB-GENE-991397
Pan troglodytes	472105		PANTR38940
Canis lupus familiaris	484095		CANLF00302
Danio rerio	494131	Xenbase:XB-GENE-991397	DANRE11173
Macaca mulatta	715520		MACMU33737
Monodelphis domestica	100029974		MONDO12051
Equus caballus	100067090		HORSE02105
Sus scrofa	100152099		PIGXX13558

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements