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aldehyde dehydrogenase 2 family member

Summary

Gene Symbol

Aldh2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29539

PubChem

29539

Alliance of Genome Resources

RGD:69219

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Mitochondrion
NAD
Oxidoreductase
Reference proteome
Transit peptide
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P11884	ALDH class 2 ALDH-E2 ALDH1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
intrinsic apoptotic signaling pathway in response to oxidative stress	IMP	29589772
regulation of dopamine biosynthetic process	ISO ISS
response to ischemia	IEP	30131474
response to organic cyclic compound	IMP	29589772
cellular detoxification of aldehyde	IMP	29589772

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

nitroglycerin metabolic process

catabolic process [inference]

cellular catabolic process [inference]

aldehyde catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic substance catabolic process [inference]

aldehyde catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

xenobiotic metabolic process [inference]

nitroglycerin metabolic process

cellular catabolic process [inference]

aldehyde catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

ethanol metabolic process

ethanol catabolic process

primary alcohol catabolic process [inference]

ethanol catabolic process

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

nitroglycerin metabolic process

organic substance catabolic process [inference]

aldehyde catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

ethanol metabolic process

ethanol catabolic process

primary alcohol catabolic process [inference]

ethanol catabolic process

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to oxidative stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to oxidative stress

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

xenobiotic metabolic process [inference]

nitroglycerin metabolic process

cellular catabolic process [inference]

aldehyde catabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to organic cyclic compound [inference]

cellular response to resveratrol

cellular response to oxygen-containing compound [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

apoptotic mitochondrial changes

cellular detoxification [inference]

cellular detoxification of aldehyde

multicellular organismal process [inference]

behavior [inference]

adult behavior [inference]

behavioral response to ethanol

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

liver development

response to stimulus [inference]

response to stress [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to increased oxygen levels [inference]

response to hyperoxia

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

response to steroid hormone [inference]

response to progesterone

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

cellular response to hormone stimulus

response to steroid hormone [inference]

response to progesterone

response to organic cyclic compound

response to stilbenoid [inference]

response to resveratrol [inference]

cellular response to resveratrol

response to steroid hormone [inference]

response to progesterone

cellular response to organic cyclic compound [inference]

cellular response to resveratrol

response to lipid [inference]

response to steroid hormone [inference]

response to progesterone

response to fatty acid [inference]

cellular response to fatty acid

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to organic cyclic compound [inference]

cellular response to resveratrol

response to alcohol [inference]

response to ethanol

response to ketone [inference]

response to nicotine

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to organic cyclic compound [inference]

cellular response to resveratrol

cellular response to oxygen-containing compound [inference]

response to oxygen-containing compound [inference]

response to fatty acid [inference]

cellular response to fatty acid

response to alcohol [inference]

response to ethanol

response to ketone [inference]

cellular response to oxygen-containing compound [inference]

response to resveratrol [inference]

cellular response to resveratrol

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to organic cyclic compound [inference]

cellular response to resveratrol

cellular response to oxygen-containing compound [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

regulation of dopamine biosynthetic process

regulation of reactive oxygen species metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of amine metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

regulation of dopamine biosynthetic process

regulation of serotonin biosynthetic process

regulation of primary metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

regulation of dopamine biosynthetic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of response to stress [inference]

regulation of response to oxidative stress

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to oxidative stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to oxidative stress

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

regulation of dopamine biosynthetic process

regulation of reactive oxygen species metabolic process

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

detoxification [inference]

cellular detoxification [inference]

cellular detoxification of aldehyde

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion	ISO	34800366
mitochondrial matrix	IDA IEA	29491208

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	23403928
carboxylesterase activity	ISO ISS
NADH binding	IDA	21276780
nitroglycerin reductase activity
aldehyde dehydrogenase (NAD+) activity	IBA IDA IMP ISO	18787169 4149764

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on other nitrogenous compounds as donors [inference]

oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [inference]

nitroglycerin reductase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity

phenylacetaldehyde dehydrogenase activity

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

carboxylesterase activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NADH binding

flavin adenine dinucleotide binding

ion binding [inference]

anion binding [inference]

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NADH binding

flavin adenine dinucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aldehyde

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 6** entries
InterPro
Aldehyde dehydrogenase domain
Aldehyde dehydrogenase, C-terminal
Aldehyde dehydrogenase, N-terminal
Aldehyde dehydrogenase, cysteine active site
Aldehyde dehydrogenase, glutamic acid active site
Aldehyde/histidinol dehydrogenase

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
mitochondrial matrix	PMID:29491208

Disease

Disease Ontology

Displaying entries **1 - 10** of 17 in total

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DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:114	heart disease	Alliance of Genome Resources
DOID:14018	alcoholic liver cirrhosis	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:3454	brain infarction	Alliance of Genome Resources
DOID:409	liver disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	217		HGNC:404
Mus musculus	11669	10090_1:0016c1	MGI:99600
Drosophila melanogaster	34256		FB:FBgn0012036
Caenorhabditis elegans	175691		WB:WBGene00000107
Caenorhabditis elegans	187001		WB:WBGene00000108
Mus musculus	338350			MOUSE46337
Danio rerio	368239		ZFIN:ZDB-GENE-030326-5
Danio rerio	393462		ZFIN:ZDB-GENE-040426-1262
Xenopus tropicalis	448267		Xenbase:XB-GENE-490836
Saccharomyces cerevisiae S288C	854556		SGD:S000005901

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Annotation

OrthoDB (Group)

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Acknowledgements