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vasoactive intestinal peptide receptor 2

Summary

Gene Symbol

Vipr2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29555

PubChem

29555

Alliance of Genome Resources

RGD:3962

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P35000	Pituitary adenylate cyclase-activating polypeptide type III receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cell surface receptor signaling pathway	IEA
negative regulation of smooth muscle cell proliferation	IMP	20452385
activation of adenylate cyclase activity	IDA	8224221
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of catalytic activity [inference]

regulation of cyclase activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of lyase activity [inference]

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
peptide hormone binding	IBA
G protein-coupled peptide receptor activity	IBA
vasoactive intestinal polypeptide receptor activity	IBA IDA	8224221

GO Hierarchy

molecular function

binding [inference]

amide binding [inference]

peptide binding [inference]

peptide hormone binding

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

vasoactive intestinal polypeptide receptor 2

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
G protein-coupled peptide receptor activity
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cell surface receptor signaling pathway
peptide hormone binding
vasoactive intestinal polypeptide receptor activity

Displaying **all 7** entries
InterPro
GPCR family 2, extracellular hormone receptor domain superfamily
GPCR, family 2, extracellular hormone receptor domain
GPCR, family 2, secretin-like, conserved site
GPCR, family 2, secretin-like
GPCR, family 2, vasoactive intestinal peptide receptor 2
GPCR, family 2, vasoactive intestinal peptide receptor
GPCR, family 2-like, 7TM

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7434		HGNC:12695	HUMAN92295
Mus musculus	22355	10090_1:003c72	MGI:107166	MOUSE08619
Drosophila melanogaster	31234		FB:FBgn0260753
Danio rerio	81886		ZFIN:ZDB-GENE-010406-4	DANRE25669
Caenorhabditis elegans	191374		WB:WBGene00014035
Canis lupus familiaris	611663			CANLF04630
Macaca mulatta	706344			MACMU31205
Bos taurus	790124			BOVIN28840
Monodelphis domestica	100021265			MONDO35321
Equus caballus	100057396			HORSE31934