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sodium voltage-gated channel alpha subunit 10

Summary

Gene Symbol

Scn10a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29571

PubChem

29571

Alliance of Genome Resources

RGD:3629

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Reference proteome
Repeat
Sodium channel
Transmembrane helix
Ubl conjugation
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
Q62968	Peripheral nerve sodium channel 3 Sensory neuron sodium channel Sodium channel protein type X subunit alpha Voltage-gated sodium channel subunit alpha Nav1.8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
regulation of heart rate	ISO
regulation of heart rate	IBA
sodium ion transport	ISO
sodium ion transport	IDA	8538791
circadian rhythm	ISO

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

multicellular organismal process [inference]

behavior [inference]

behavioral response to pain

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus involved in sensory perception

detection of stimulus involved in sensory perception of pain [inference]

detection of temperature stimulus involved in sensory perception of pain

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of ion transmembrane transport

regulation of cellular process [inference]

regulation of membrane depolarization [inference]

regulation of atrial cardiac muscle cell membrane depolarization

regulation of transmembrane transport [inference]

regulation of ion transmembrane transport

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of biological quality [inference]

regulation of heart rate

regulation of membrane potential [inference]

action potential [inference]

neuronal action potential

cardiac muscle cell action potential [inference]

regulation of membrane depolarization [inference]

regulation of atrial cardiac muscle cell membrane depolarization

membrane depolarization [inference]

membrane depolarization during action potential

membrane depolarization during cardiac muscle cell action potential

regulation of presynaptic membrane potential

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GO Term	Evidence Code	PMID
voltage-gated sodium channel complex	ISO
voltage-gated sodium channel complex	IBA
plasma membrane	ISS
plasma membrane	ISO
axon	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

clathrin complex

plasma membrane protein complex [inference]

voltage-gated sodium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

C-fiber

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GO Term	Evidence Code	PMID
voltage-gated sodium channel activity	ISO
voltage-gated sodium channel activity	IDA	8538791
protein binding	IPI	12050667 12591166 15797711
transmembrane transporter binding	ISO
voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

binding [inference]

protein binding

transmembrane transporter binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sodium channel protein

Functional Category

E: Amino acid transport and metabolism
K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
membrane depolarization during action potential
monoatomic ion channel activity
monoatomic ion transport
neuronal action potential
sodium channel activity
sodium ion transmembrane transport
voltage-gated sodium channel activity

Displaying **all 7** entries
InterPro
Ion transport domain
Sodium ion transport-associated domain
Voltage gated sodium channel, alpha subunit
Voltage-dependent channel domain superfamily
Voltage-gated Na+ ion channel, cytoplasmic domain
Voltage-gated cation channel calcium and sodium
Voltage-gated sodium channel alpha subunit, inactivation gate

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
clathrin complex	PMID:15797711

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:11446	sciatic neuropathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **113** in total

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Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	773	SGD:S000003449
Saccharomyces cerevisiae S288C	774	SGD:S000003449
Saccharomyces cerevisiae S288C	775	SGD:S000003449
Saccharomyces cerevisiae S288C	776	SGD:S000003449
Saccharomyces cerevisiae S288C	777	SGD:S000003449
Saccharomyces cerevisiae S288C	778	SGD:S000003449
Saccharomyces cerevisiae S288C	779	SGD:S000003449
Saccharomyces cerevisiae S288C	6323	SGD:S000003449
Saccharomyces cerevisiae S288C	6326	SGD:S000003449
Saccharomyces cerevisiae S288C	6328	SGD:S000003449