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Guidelines

MIRAGE

general transcription factor IIE subunit 2

Summary

Gene Symbol

GTF2E2

Organism

Homo sapiens (human)

External Links

NCBI Gene

2961

PubChem

2961

Alliance of Genome Resources

HGNC:4651

Annotation

Keyword

3D-structure
Acetylation
DNA-binding
Direct protein sequencing
Disease variant
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transcription regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
P29084	General transcription factor IIE subunit 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
transcription by RNA polymerase II	IDA	27193682
transcription initiation at RNA polymerase II promoter	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleoplasm	TAS
nucleoplasm	IDA
transcription factor TFIID complex	IDA	27193682
transcription factor TFIIE complex	IBA
cytosol	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

transcription regulator complex [inference]

RNA polymerase II transcription regulator complex [inference]

nuclear protein-containing complex [inference]

RNA polymerase II transcription regulator complex [inference]

cellular anatomical entity [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
TFIIH-class transcription factor complex binding	IBA
DNA binding	IEA
RNA binding	HDA	22658674
protein binding	IPI	16547462 21988832 28514442 32296183 33961781 7926747 8999876 9271120
RNA polymerase II general transcription initiation factor activity	IDA	27193682

GO Hierarchy

molecular function

binding [inference]

protein binding

basal transcription machinery binding [inference]

basal RNA polymerase II transcription machinery binding [inference]

RNA polymerase II general transcription initiation factor binding [inference]

TFIIH-class transcription factor complex binding

transcription factor binding [inference]

general transcription initiation factor binding [inference]

RNA polymerase II general transcription initiation factor binding [inference]

TFIIH-class transcription factor complex binding

protein-containing complex binding [inference]

TFIIH-class transcription factor complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

general transcription initiation factor activity [inference]

RNA polymerase II general transcription initiation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transcription initiation factor iie beta subunit

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
TFIIH-class transcription factor complex binding
transcription initiation at RNA polymerase II promoter

Displaying **all 5** entries
InterPro
TFA2, Winged helix domain 2
Transcription factor TFIIE beta subunit, DNA-binding domain
Transcription initiation factor TFIIE, beta subunit
Winged helix DNA-binding domain superfamily
Winged helix-like DNA-binding domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111872	nonphotosensitive trichothiodystrophy 6	Alliance of Genome Resources

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025