GlyCosmos Portal

Submissions

glutamate ionotropic receptor AMPA type subunit 2

Summary

Gene Symbol

Gria2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29627

PubChem

29627

Alliance of Genome Resources

RGD:61862

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Palmitate
Phosphoprotein
Postsynaptic cell membrane
RNA editing
Receptor
Reference proteome
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P19491	AMPA-selective glutamate receptor 2 GluR-B GluR-K2 Glutamate receptor ionotropic, AMPA 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	PMID
regulation of receptor recycling	IMP	11348590
chemical synaptic transmission	ISO
chemical synaptic transmission	IDA	12554656
response to lithium ion	IEP	15269270
calcium-mediated signaling	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to amine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to amine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

developmental process [inference]

anatomical structure development [inference]

cerebral cortex development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

response to nerve growth factor [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to amine stimulus

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

response to glycine [inference]

cellular response to glycine

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

response to toxic substance [inference]

response to fungicide

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amine [inference]

cellular response to amine stimulus

response to amino acid [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

response to glycine [inference]

cellular response to glycine

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to amine stimulus

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to amine stimulus

response to inorganic substance [inference]

response to metal ion [inference]

response to lithium ion

response to antibiotic [inference]

response to fungicide

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to amine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to amine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

cellular response to amine stimulus

response to amino acid [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

response to glycine [inference]

cellular response to glycine

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to amine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to amine stimulus

response to oxygen-containing compound [inference]

response to lithium ion

response to amino acid [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

response to glycine [inference]

cellular response to glycine

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

response to salt [inference]

response to lithium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to amine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to amine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

establishment of protein localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling

regulation of signaling [inference]

regulation of receptor recycling

positive regulation of signaling [inference]

positive regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity [inference]

regulation of long-term synaptic depression

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity [inference]

regulation of long-term synaptic depression

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

regulation of presynaptic membrane potential

regulation of synaptic plasticity [inference]

regulation of long-term synaptic depression

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GO Term	Evidence Code	PMID
endoplasmic reticulum	ISO
plasma membrane	ISO
plasma membrane	TAS
plasma membrane	IDA	21846932
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

AMPA glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

AMPA glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

AMPA glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

AMPA glutamate receptor complex

cellular anatomical entity [inference]

extracellular region [inference]

perisynaptic space

cytoplasm [inference]

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

dendrite cytoplasm

cell surface

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

dendrite membrane

synaptic membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

neuron to neuron synapse [inference]

asymmetric synapse

spine synapse

site of polarized growth [inference]

growth cone

leading edge membrane [inference]

neuron projection membrane [inference]

dendrite membrane

somatodendritic compartment

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

side of membrane [inference]

external side of plasma membrane

presynapse

terminal bouton

postsynapse [inference]

dendritic spine

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GO Term	Evidence Code	PMID
SNARE binding	IPI	11931741
amyloid-beta binding	IPI	20032460
glutamate-gated receptor activity	ISO
glutamate-gated receptor activity	TAS	12554656
glutamate-gated receptor activity	IDA	19946266 21846932

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glutamate-gated ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

AMPA glutamate receptor activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glutamate-gated ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glutamate-gated ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

amide transmembrane transporter activity [inference]

glutamate-gated receptor activity

salt transmembrane transporter activity [inference]

glutamate-gated receptor activity

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

binding [inference]

protein binding

SNARE binding

signaling receptor binding [inference]

glutamate receptor binding

ionotropic glutamate receptor binding

cytoskeletal protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein domain specific binding [inference]

PDZ domain binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

protein-containing complex binding

immunoglobulin binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

glutamate receptor activity [inference]

glutamate-gated receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glutamate

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ligand-gated monoatomic ion channel activity
monoatomic ion transport

Displaying **all 2** entries
InterPro
Periplasmic binding protein-like I
Receptor, ligand binding region

Alliance of Genome Resources

Expression

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Location	References
protein-containing complex	PMID:17329210
cell surface	PMID:19321442 PMID:24712995
asymmetric synapse	PMID:12077196
dendritic spine neck	PMID:11007883
external side of plasma membrane	PMID:19674091
dendritic shaft	PMID:10414981 PMID:11007883 PMID:11978826 PMID:12077196 PMID:16157387 PMID:19160501
growth cone	PMID:12554656
dendrite membrane	PMID:11931740
dendrite	PMID:12629171 PMID:15844209 PMID:15965473 PMID:21807099 PMID:21847098 PMID:26109571
dendritic spine	PMID:12077196 PMID:16157387 PMID:17207780

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9975	cocaine dependence	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 96 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	2890	FB:FBgn0264000
Homo sapiens	2891	ZFIN:ZDB-GENE-020125-4	HUMAN77911
Drosophila melanogaster	2892	FB:FBgn0264000
Drosophila melanogaster	2893	FB:FBgn0264000
Caenorhabditis elegans	2897	WB:WBGene00001612
Caenorhabditis elegans	2898	WB:WBGene00001612
Caenorhabditis elegans	2899	WB:WBGene00001612
Drosophila melanogaster	14799	FB:FBgn0264000
Mus musculus	14800	ZFIN:ZDB-GENE-020125-4	MOUSE36764
Drosophila melanogaster	14802	FB:FBgn0264000

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OrthoDB (Group)

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Acknowledgements