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ADAM metallopeptidase domain 10

Summary

Gene Symbol

Adam10

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29650

PubChem

29650

Alliance of Genome Resources

RGD:2032

Annotation

Keyword

Cell junction
Cell membrane
Cell projection
Cleavage on pair of basic residues
Cytoplasm
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Golgi apparatus
Metal-binding
Metalloprotease
Notch signaling pathway
Phosphoprotein
Reference proteome
SH3-binding
Signal
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q10743	Kuzbanian protein homolog Mammalian disintegrin-metalloprotease

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 34 in total

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GO Term	Evidence Code	PMID
membrane protein ectodomain proteolysis	IBA ISO ISS
positive regulation of cell growth	IEA ISO
regulation of dendritic spine morphogenesis	IMP	22328515
amyloid precursor protein catabolic process	IEA ISO
positive regulation of apoptotic process	IMP	21503882

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

monocyte activation

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

amyloid-beta metabolic process [inference]

amyloid-beta formation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

constitutive protein ectodomain proteolysis

protein catabolic process [inference]

protein catabolic process at synapse [inference]

protein catabolic process at postsynapse

protein modification process [inference]

protein phosphorylation

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

protein catabolic process at synapse [inference]

protein catabolic process at postsynapse

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process at synapse [inference]

protein catabolic process at postsynapse

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

protein catabolic process at synapse [inference]

protein catabolic process at postsynapse

hormone metabolic process [inference]

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

constitutive protein ectodomain proteolysis

protein catabolic process [inference]

protein catabolic process at synapse [inference]

protein catabolic process at postsynapse

protein modification process [inference]

protein phosphorylation

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process at synapse [inference]

protein catabolic process at postsynapse

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

constitutive protein ectodomain proteolysis

protein catabolic process [inference]

protein catabolic process at synapse [inference]

protein catabolic process at postsynapse

protein modification process [inference]

protein phosphorylation

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

constitutive protein ectodomain proteolysis

protein catabolic process [inference]

protein catabolic process at synapse [inference]

protein catabolic process at postsynapse

protein modification process [inference]

protein phosphorylation

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

protein catabolic process at synapse [inference]

protein catabolic process at postsynapse

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process at synapse [inference]

protein catabolic process at postsynapse

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

protein catabolic process at synapse [inference]

protein catabolic process at postsynapse

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

monocyte activation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

pore complex assembly

cell junction organization [inference]

cell-cell junction organization [inference]

adherens junction organization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

pore complex assembly

postsynapse organization

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

monocyte activation

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

cochlea development

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to tumor necrosis factor

response to antineoplastic agent

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte migration [inference]

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of T cell migration [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

regulation of osteoclast differentiation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to cell periphery [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to membrane [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of receptor localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte migration [inference]

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of T cell migration [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cell adhesion

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendritic spine morphogenesis

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

regulation of osteoclast differentiation

regulation of multicellular organismal development [inference]

regulation of vasculature development

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

regulation of osteoclast differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

regulation of osteoclast differentiation

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

negative regulation of cellular process [inference]

negative regulation of cell adhesion

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular component organization

regulation of cell growth [inference]

positive regulation of cell growth

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendritic spine morphogenesis

regulation of synapse organization [inference]

regulation of postsynapse organization

regulation of dendritic spine morphogenesis

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to cell periphery [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to membrane [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte migration [inference]

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of T cell migration [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of vasculature development

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

regulation of osteoclast differentiation

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
postsynaptic membrane	IDA	17301176
pore complex	IEA ISO
Golgi apparatus	ISO ISS
postsynaptic density	IEA ISO
postsynapse	IDA	17301176 22328515

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

synaptic membrane

postsynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

postsynapse

dendritic spine

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IBA IEA ISO
SH3 domain binding	IEA
metallodipeptidase activity	IEA ISO
metal ion binding	IEA
metalloendopeptidase activity	IDA IEA ISO	10423016

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metallopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallodipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metallopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallodipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein domain specific binding [inference]

SH3 domain binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

disintegrin and metalloproteinase domain-containing protein 10

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 8** entries
Gene Ontology
SH3 domain binding
membrane protein ectodomain proteolysis
metal ion binding
metalloendopeptidase activity involved in amyloid precursor protein catabolic process
metalloendopeptidase activity
metallopeptidase activity
proteolysis
regulation of cellular component organization

Displaying **all 6** entries
InterPro
ADAM10, cysteine-rich domain
ADAM10/ADAM17 catalytic domain
Disintegrin domain superfamily
Disintegrin domain
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
cell surface	PMID:21503882
dendrite	PMID:25429624
synaptic vesicle	PMID:26296617
neuronal cell body	PMID:25429624
trans-Golgi network	PMID:10423016
postsynapse	PMID:22328515

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0060258	reticulate acropigmentation of Kitamura	Alliance of Genome Resources
DOID:0081292	traumatic brain injury	Alliance of Genome Resources
DOID:0110050	Alzheimer's disease 18	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:14004	thoracic aortic aneurysm	Alliance of Genome Resources
DOID:1824	status epilepticus	Alliance of Genome Resources
DOID:83	cataract	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of **117** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	733451	Xenbase:XB-GENE-945388
Pan troglodytes	746942		PANTR10428
Monodelphis domestica	100027329		MONDO09173
Ornithorhynchus anatinus	100074755		ORNAN26584
Oryctolagus cuniculus	100101614		RABIT06021
Pongo abelii	100169741		PONAB08858
Taeniopygia guttata	100219653		TAEGU02248
Callithrix jacchus	100415138		CALJA00744
Ailuropoda melanoleuca	100476350		AILME02420
Anolis carolinensis	100553674		ANOCA12765

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements