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OMA1 zinc metallopeptidase

Summary

Gene Symbol

Oma1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

298282

PubChem

298282

Alliance of Genome Resources

RGD:1304821

Annotation

Keyword

Autocatalytic cleavage
Disulfide bond
Lipid-binding
Metal-binding
Metalloprotease
Mitochondrion inner membrane
Reference proteome
Transit peptide
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
D3ZS74	Overlapping with the m-AAA protease 1 homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
lipid metabolic process	IEA ISO ISS
positive regulation of cold-induced thermogenesis	IEA ISO ISS	22433842
energy homeostasis	ISO ISS
protein autoprocessing	IEA ISO ISS
proteolysis	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein maturation [inference]

protein processing [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

lipid metabolic process

protein metabolic process [inference]

proteolysis

protein processing [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein maturation [inference]

protein processing [inference]

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

lipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein maturation [inference]

protein processing [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein maturation [inference]

protein processing [inference]

adaptive thermogenesis [inference]

diet induced thermogenesis

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

integrated stress response signaling

HRI-mediated signaling

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization [inference]

cristae formation

cellular component assembly [inference]

protein-containing complex assembly [inference]

mitochondrial respiratory chain complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

mitochondrial respiratory chain complex assembly

membrane organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization [inference]

cristae formation

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

integrated stress response signaling

HRI-mediated signaling

cellular response to stimulus [inference]

cellular response to stress [inference]

integrated stress response signaling

HRI-mediated signaling

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

negative regulation of developmental process [inference]

negative regulation of mitochondrial fusion

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of mitochondrial fusion [inference]

negative regulation of mitochondrial fusion

negative regulation of developmental process [inference]

negative regulation of mitochondrial fusion

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of mitochondrion organization [inference]

regulation of mitochondrial fusion [inference]

negative regulation of mitochondrial fusion

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of cristae formation

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IBA IEA ISO ISS
mitochondrial membrane	ISO ISS
mitochondrial intermembrane space	ISO
mitochondrion	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	IBA IDA IEA ISO ISS	33200421
lipid binding	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

lipid binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	100331186	ZFIN:ZDB-GENE-091204-124	DANRE19319
Astyanax mexicanus	103027560		ASTMX12775
Ictalurus punctatus	108257956		ICTPU20247
Esox lucius	105011716		ESOLU24409
Salmo salar	106584268		SALSA86230
Salmo trutta	115192421		SALTR29721
Gadus morhua	115555174		GADMO06623
Haplochromis burtoni	102308782		HAPBU09178
Sparus aurata	115590935		SPAAU67884
Chrysemys picta bellii	101952012		CHRPI04285