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glutamate ionotropic receptor kainate type subunit 3

Summary

Gene Symbol

Grik3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

298521

PubChem

298521

Alliance of Genome Resources

RGD:71027

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Isopeptide bond
Ligand-gated ion channel
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 4** entries
UniProt	Protein Name
P42264	Glutamate receptor 7
G3V9I2
A6IS78
A6IS79

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA
glutamate receptor signaling pathway	ISO
G protein-coupled glutamate receptor signaling pathway	ISO
chemical synaptic transmission	NAS	9390526
calcium-mediated signaling	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

ionotropic glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

transmembrane transport [inference]

monoatomic ion transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

regulation of synaptic transmission, glutamatergic [inference]

negative regulation of synaptic transmission, glutamatergic

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

ionotropic glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

regulation of synaptic transmission, glutamatergic [inference]

negative regulation of synaptic transmission, glutamatergic

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

regulation of biological quality [inference]

regulation of membrane potential

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IBA
axon	IDA	15844209
dendrite	IDA	16360275 16420445
dendrite cytoplasm	IDA	15844209

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

kainate selective glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

kainate selective glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

kainate selective glutamate receptor complex

cation channel complex [inference]

potassium channel complex [inference]

kainate selective glutamate receptor complex

sodium channel complex [inference]

kainate selective glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

kainate selective glutamate receptor complex

cation channel complex [inference]

potassium channel complex [inference]

kainate selective glutamate receptor complex

sodium channel complex [inference]

kainate selective glutamate receptor complex

cellular anatomical entity [inference]

cytoplasm [inference]

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

dendrite cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

ribbon synapse [inference]

cochlear hair cell ribbon synapse

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

perikaryon

presynapse [inference]

terminal bouton

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	ISO
adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IEA
glutamate-gated receptor activity	ISO
glutamate-gated receptor activity	IDA	11124978 1322826 1371217
glutamate-gated receptor activity	IMP	21907808

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

amide transmembrane transporter activity [inference]

glutamate-gated receptor activity

salt transmembrane transporter activity [inference]

glutamate-gated receptor activity

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

binding [inference]

protein binding

identical protein binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity

glutamate receptor activity

glutamate-gated receptor activity

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GLUTAMATE RECEPTOR

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ligand-gated monoatomic ion channel activity
modulation of chemical synaptic transmission
monoatomic ion channel activity
monoatomic ion transport
synaptic transmission, glutamatergic
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Displaying **all 6** entries
InterPro
Ionotropic glutamate receptor, C-terminal
Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Ionotropic glutamate receptor, metazoa
Ionotropic glutamate receptor
Periplasmic binding protein-like I
Receptor, ligand binding region

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
dendrite cytoplasm	PMID:15844209
axon	PMID:15844209
perikaryon	PMID:15844209
dendrite	PMID:16360275
terminal bouton	PMID:15844209

Ortholog

Displaying entries **1 - 10** of **107** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	2890	WB:WBGene00001612
Caenorhabditis elegans	2891	WB:WBGene00001612
Caenorhabditis elegans	2892	WB:WBGene00001612
Caenorhabditis elegans	2893	WB:WBGene00001612
Drosophila melanogaster	2897	FB:FBgn0039916
Drosophila melanogaster	2898	FB:FBgn0039916
Homo sapiens	2899	Xenbase:XB-GENE-6050069	HUMAN48892
Drosophila melanogaster	2900	FB:FBgn0039916
Drosophila melanogaster	2901	FB:FBgn0039916
Caenorhabditis elegans	14799	WB:WBGene00001612

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OrthoDB (Group)

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