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ALG5 dolichyl-phosphate beta-glucosyltransferase

Summary

Gene Symbol

ALG5

Aliases

bA421P11.2

Organism

Homo sapiens (human)

External Links

NCBI Gene

29880

GGDB ID

gg145

HGNC

20266

mRNA

NM_013338

map

13q13.3

Protein

NP_037470

OMIM

604565

KEGG Gene ID

hsa:29880

PubChem

29880

Alliance of Genome Resources

HGNC:20266

Annotation

Keyword

Alternative splicing
Disease variant
Endoplasmic reticulum
Glycosyltransferase
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y673	Asparagine-linked glycosylation protein 5 homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation via asparagine	TAS
protein N-linked glycosylation	IBA IMP	10359825
dolichol-linked oligosaccharide biosynthetic process	IMP	10359825
determination of left/right symmetry	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

multicellular organismal process [inference]

pattern specification process [inference]

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	HDA	19946888
endoplasmic reticulum membrane	IBA TAS
cytoplasmic side of rough endoplasmic reticulum membrane	IGI	10359825

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane [inference]

cytoplasmic side of rough endoplasmic reticulum membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32353859 32838362 33060197 36217030
dolichyl-phosphate beta-glucosyltransferase activity	IGI TAS	10359825

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-glucosyltransferase activity [inference]

dolichyl-phosphate beta-glucosyltransferase activity

hexosyltransferase activity [inference]

glucosyltransferase activity [inference]

UDP-glucosyltransferase activity [inference]

dolichyl-phosphate beta-glucosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dolichyl-phosphate beta-glucosyltransferase

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
dolichyl-phosphate beta-glucosyltransferase activity

Displaying **all 3** entries
InterPro
Dolichyl-phosphate beta-glucosyltransferase
Glycosyltransferase 2-like
Nucleotide-diphospho-sugar transferases

GlycoGene Database (GGDB)

GGDB ID

gg145

Gene Symbol

ALG5

Orthologous Gene

Displaying **all 6** entries
Species	Protein	mRNA
Saccharomyces cerevisiae	CAA97942	Z73583
Drosophila melanogaster	NP_609202	NM_135358
Rattus norvegicus	XP_215561	XM_215561
Caenorhabditis elegans	NP_741523	NM_171446
Mus musculus	NP_079718	NM_025442
Arabidopsis thaliana	NP_181493	NM_129519

KEGG BRITE Database

Orthology

K00729

Name

dolichyl-phosphate beta-glucosyltransferase [EC:2.4.1.117]

References

8076653

Rhea

RHEA:15401

UDP-α-D-glucose

UDP

Enzyme

2.4.1.117

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050570	congenital disorder of glycosylation type I	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 29 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000010	Recurrent urinary tract infections
HP:0000083	Renal insufficiency
HP:0000105	Enlarged kidney
HP:0000107	Renal cyst
HP:0000790	Hematuria
HP:0000791	Uric acid nephrolithiasis
HP:0000822	Hypertension
HP:0001407	Hepatic cysts
HP:0001634	Mitral valve prolapse

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:620056	polycystic kidney disease 7
ORPHA:730	autosomal dominant polycystic kidney disease

PubChem Disease

MedGen Diseases

Polycystic kidney disease 7

OMIM Phenotypes

POLYCYSTIC KIDNEY DISEASE 7; PKD7

KEGG Diseases

Polycystic kidney disease

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012355
Gene Name: ALG5, dolichyl-phosphate beta-glucosyltransferase

Ortholog

Displaying entries **41 - 50** of 85 in total

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Species	Gene ID	Orthologous MAtrix
Chinchilla lanigera	102026779	CHILA09183
Macaca fascicularis	102136561	MACFA15351
Capra hircus	102185475	CAPHI03036
Latimeria chalumnae	102367426	LATCH07064
Myotis lucifugus	102437155	MYOLU02949
Chlorocebus sabaeus	103214290	CHLSB13651
Carlito syrichta	103250320	CARSF25219
Ursus maritimus	103664420	URSMA13570
Nannospalax galili	103745206	NANGA24500
Serinus canaria	103827368	SERCA01670

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements