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Guidelines

MIRAGE

cleavage and polyadenylation specific factor 1

Summary

Gene Symbol

CPSF1

Organism

Homo sapiens (human)

External Links

NCBI Gene

29894

PubChem

29894

Alliance of Genome Resources

HGNC:2324

Annotation

Keyword

3D-structure
Disease variant
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
mRNA processing

Proteins

Displaying 1 entry
UniProt	Protein Name
Q10570	Cleavage and polyadenylation specificity factor 160 kDa subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mRNA processing	IEA
co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway	IC	7590244

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA
mRNA cleavage and polyadenylation specificity factor complex	IDA	21102410 7590244
mRNA cleavage and polyadenylation specificity factor complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

mRNA cleavage factor complex [inference]

mRNA cleavage and polyadenylation specificity factor complex

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21102410 21822216 25416956 32296183 7590244
enzyme binding	IPI	7590244
mRNA 3'-UTR AU-rich region binding	IDA	7590244

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

mRNA binding [inference]

mRNA 3'-UTR binding [inference]

mRNA 3'-UTR AU-rich region binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cleavage and polyadenylation specificity factor

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
mRNA polyadenylation

Displaying **all 3** entries
InterPro
Cleavage/polyadenylation specificity factor, A subunit, C-terminal
Cleavage/polyadenylation specificity factor, A subunit, N-terminal
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:11830	myopia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 59 in total

1

2

3

4

5

6

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	29894	Xenbase:XB-GENE-5881773
Mus musculus	94230		MOUSE16470
Bos taurus	282703		BOVIN05532
Rattus norvegicus	366952		RATNO36946
Danio rerio	432372		DANRE15633
Canis lupus familiaris	475126		CANLF03316
Monodelphis domestica	100015835		MONDO19193
Equus caballus	100063277		HORSE43121
Callithrix jacchus	100401197		CALJA13431
Loxodonta africana	100662639		LOXAF01035

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025