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pyrroline-5-carboxylate reductase 2

Summary

Gene Symbol

PYCR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

29920

PubChem

29920

Alliance of Genome Resources

HGNC:30262

JoGo

PYCR2

TogoVar

PYCR2

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Disease variant
Leukodystrophy
Mitochondrion
NADP
Oxidoreductase
Phosphoprotein
Proline biosynthesis
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A0S2Z5U6
Q96C36
A0A087WTV6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
proline biosynthetic process	IDA	23024808
cellular response to oxidative stress	IMP	25865492
L-proline biosynthetic process	IBA
L-proline biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

heterocycle biosynthetic process [inference]

L-proline biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

organic cyclic compound biosynthetic process [inference]

L-proline biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

heterocycle biosynthetic process [inference]

L-proline biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

L-proline biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

organic cyclic compound metabolic process [inference]

organic cyclic compound biosynthetic process [inference]

L-proline biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

organic cyclic compound biosynthetic process [inference]

L-proline biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

heterocycle biosynthetic process [inference]

L-proline biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

L-proline biosynthetic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrion	IDA	23024808 25865492
mitochondrion	HTP	34800366
mitochondrial matrix	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
pyrroline-5-carboxylate reductase activity	IDA	23024808
pyrroline-5-carboxylate reductase activity	IBA
protein binding	IPI	24930674

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH group of donors [inference]

oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [inference]

pyrroline-5-carboxylate reductase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

pyrroline-5- carboxylate reductase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 5** entries
Gene Ontology
L-proline biosynthetic process
amino acid biosynthetic process
oxidoreductase activity
proline biosynthetic process
pyrroline-5-carboxylate reductase activity

Displaying **all 5** entries
InterPro
6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
NAD(P)-binding domain superfamily
Pyrroline-5-carboxylate reductase, catalytic, N-terminal
Pyrroline-5-carboxylate reductase, dimerisation domain
Pyrroline-5-carboxylate reductase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060788	hypomyelinating leukodystrophy 10	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements