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fibronectin leucine rich transmembrane protein 2

Summary

Gene Symbol

Flrt2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

299236

PubChem

299236

Alliance of Genome Resources

RGD:1308574

Annotation

Keyword

Cell adhesion
Cell junction
Cell membrane
Developmental protein
Disulfide bond
Extracellular matrix
Glycoprotein
Leucine-rich repeat
Microsome
Reference proteome
Repeat
Signal
Synaptosome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
D3ZTV3	Fibronectin-like domain-containing leucine-rich transmembrane protein 2

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
heart morphogenesis	ISS
heart morphogenesis	ISO
axon guidance	ISO
fibroblast growth factor receptor signaling pathway	ISS
fibroblast growth factor receptor signaling pathway	ISO

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell adhesion involved in heart morphogenesis

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

extracellular structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

heart morphogenesis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of neuron migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of neuron migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IBA
endoplasmic reticulum membrane	IEA
plasma membrane	ISS
plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-cell junction

cell-substrate junction [inference]

focal adhesion

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying **all 2** entries
GO Term	Evidence Code	PMID
fibroblast growth factor receptor binding	ISO
chemorepellent activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

chemorepellent activity

growth factor receptor binding [inference]

fibroblast growth factor receptor binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

leucine-rich repeat transmembrane

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
InterPro
Cysteine-rich flanking region, C-terminal
Fibronectin type III superfamily
Fibronectin type III
Leucine-rich repeat N-terminal domain
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat

Ortholog

Displaying entries **1 - 10** of **116** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	23768	Xenbase:XB-GENE-495394	HUMAN20602
Xenopus tropicalis	299236	Xenbase:XB-GENE-495394
Mus musculus	399558	Xenbase:XB-GENE-495394	MOUSE08380
Pan troglodytes	453084		PANTR09296
Canis lupus familiaris	490820		CANLF18146
Bos taurus	539905		BOVIN01828
Danio rerio	571972		DANRE19187
Macaca mulatta	709329		MACMU41510
Monodelphis domestica	100016482		MONDO06601
Equus caballus	100052762		HORSE22975