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granzyme A

Summary

Gene Symbol

GZMA

Organism

Homo sapiens (human)

External Links

NCBI Gene

3001

PubChem

3001

Alliance of Genome Resources

HGNC:4708

JoGo

GZMA

TogoVar

GZMA

Annotation

Keyword

3D-structure
Alternative promoter usage
Cytolysis
Direct protein sequencing
Disulfide bond
Glycoprotein
Proteomics identification
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P12544	CTL tryptase Cytotoxic T-lymphocyte proteinase 1 Fragmentin-1 Granzyme-1 Hanukkah factor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
apoptotic process	TAS	12524539
immune response	TAS	12524539
response to bacterium	IEA
killing of cells of another organism	IEA
negative regulation of endodeoxyribonuclease activity	IDA	12524539

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

protein maturation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

protein maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

protein maturation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

protein maturation

cellular process [inference]

cell killing [inference]

killing of cells of another organism

signal transduction [inference]

granzyme-mediated programmed cell death signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

pyroptosis

cytotoxic T cell pyroptotic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of DNA metabolic process [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of DNA metabolic process [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of nuclease activity [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of DNA metabolic process [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of DNA metabolic process [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of cellular process [inference]

signal transduction [inference]

granzyme-mediated programmed cell death signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of DNA metabolic process [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of oxidoreductase activity

negative regulation of binding [inference]

negative regulation of DNA binding

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of oxidoreductase activity

regulation of hydrolase activity [inference]

regulation of nuclease activity [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of oxidoreductase activity [inference]

negative regulation of oxidoreductase activity

regulation of binding [inference]

negative regulation of binding [inference]

negative regulation of DNA binding

regulation of DNA binding [inference]

negative regulation of DNA binding

Displaying **all 4** entries
GO Term	Evidence Code	PMID
immunological synapse	TAS	12524539
extracellular space	IBA
nucleus	TAS	11909973
cytoplasm	IDA	20038786 34022140

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IDA	11331782 12819770 32299851 34022140 36899106
serine-type endopeptidase activity	IBA
protein binding	IPI	12524539
protein homodimerization activity	IDA	12819770