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SH3 domain containing kinase binding protein 1

Summary

Gene Symbol

SH3KBP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

30011

PubChem

30011

Alliance of Genome Resources

HGNC:13867

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Cell junction
Coiled coil
Cytoplasmic vesicle
Cytoskeleton
Endocytosis
Host-virus interaction
Kinase
Membrane
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH3 domain
SH3-binding
Synaptosome
Ubl conjugation

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q96B97	CD2-binding protein 3 Cbl-interacting protein of 85 kDa Human Src family kinase-binding protein 1
Q5JPT6
A0A8V8TQF6
B7Z6E8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
endocytosis	IEA
regulation of cell shape	IMP	21834987
positive regulation of B cell activation	IMP	29636373
apoptotic process	IEA
cell migration	IBA IMP	21834987

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

cell death [inference]

programmed cell death [inference]

apoptotic process

vesicle-mediated transport [inference]

endocytosis

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

supramolecular fiber organization [inference]

actin filament organization

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of lymphocyte activation [inference]

regulation of B cell activation [inference]

positive regulation of B cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

signaling [inference]

cell-cell signaling

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

positive regulation of cellular process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of lymphocyte activation [inference]

regulation of B cell activation [inference]

positive regulation of B cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of lymphocyte activation [inference]

regulation of B cell activation [inference]

positive regulation of B cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of biological quality [inference]

regulation of cell shape

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	20221403 25468996
glutamatergic synapse	IEA
GABA-ergic synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

cell junction [inference]

synapse

anchoring junction [inference]

cell-cell junction

cell-substrate junction [inference]

focal adhesion

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10679202 12177062 14596919 15090612 15962011 16164598 16228008 16256071 16751601 17255943 17306257 18641129 18680311 19111555 19268472 20221403 20551902 20711168 21516116 21900206 23178720 23663663 25036637 28514442 31413325 31980649 32296183 32814053 33961781
SH3 domain binding	IEA
ubiquitin protein ligase binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

protein domain specific binding [inference]

SH3 domain binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Guanine nucleotide exchange factor VAV2

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
SH3 domain
SH3-like domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0111999	immunodeficiency 61	Alliance of Genome Resources
DOID:1184	nephrotic syndrome	Alliance of Genome Resources
DOID:680	tauopathy	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 81 in total

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Species	Gene ID	Orthologous MAtrix
Astyanax mexicanus	103025305	ASTMX07959
Callorhinchus milii	103177511	CALMI13191
Chlorocebus sabaeus	103231684	CHLSB18325
Ursus maritimus	103668167	URSMA07914
Nannospalax galili	103736227	NANGA10782
Serinus canaria	103815842	SERCA09610
Rhinopithecus roxellana	104682409	RHIRO33789
Macaca nemestrina	105478200	MACNE09455
Mandrillus leucophaeus	105550778	MANLE22991
Cercocebus atys	105574643	CERAT03727

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements