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granzyme B

Summary

Gene Symbol

GZMB

Organism

Homo sapiens (human)

External Links

NCBI Gene

3002

PubChem

3002

Alliance of Genome Resources

HGNC:4709

Annotation

Keyword

3D-structure
Apoptosis
Cytolysis
Direct protein sequencing
Disulfide bond
Glycoprotein
Lysosome
Proteomics identification
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q6XGZ4
J3KQ52
P10144	C11 CTLA-1 Cathepsin G-like 1 Cytotoxic T-lymphocyte proteinase 2 Fragmentin-2 Granzyme-2 Human lymphocyte protein SECT T-cell serine protease 1-3E
Q67BC3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
apoptotic process	TAS	12524539
negative regulation of translation	IDA	29107333
killing of cells of another organism	IEA
natural killer cell mediated cytotoxicity	IDA	32188940
natural killer cell mediated cytotoxicity	IMP	21795594

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity [inference]

natural killer cell mediated cytotoxicity

lymphocyte mediated immunity [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

immune response [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

protein maturation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

protein maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

protein maturation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

protein maturation

cellular process [inference]

cell killing [inference]

leukocyte mediated cytotoxicity [inference]

natural killer cell mediated cytotoxicity

killing of cells of another organism

signal transduction [inference]

granzyme-mediated programmed cell death signaling pathway

cell death [inference]

programmed cell death [inference]

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

immune response [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of establishment of protein localization to mitochondrion

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of cellular process [inference]

signal transduction [inference]

granzyme-mediated programmed cell death signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of establishment of protein localization to mitochondrion

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
immunological synapse	TAS	12524539
extracellular region
extracellular space	IBA
nucleus	TAS	11909973
cytoplasm	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

cytolytic granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

cytolytic granule lumen

cytoplasmic vesicle lumen [inference]

cytolytic granule lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

cytolytic granule

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

cytolytic granule

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
serine-type endopeptidase activity	EXP	32188940
serine-type endopeptidase activity	TAS	12524539
serine-type endopeptidase activity	IDA	11331782 20038786 31953257 32188940 9852092
serine-type endopeptidase activity	IBA
protein binding	IPI	11911826 16267761

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serine protease

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity

Displaying **all 5** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site

Ortholog

Displaying entries **1 - 10** of 51 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1215	Xenbase:XB-GENE-5954079
Xenopus tropicalis	1511	Xenbase:XB-GENE-5954079
Xenopus tropicalis	2999	Xenbase:XB-GENE-5954079
Xenopus tropicalis	3002	Xenbase:XB-GENE-5954079
Xenopus tropicalis	13035	Xenbase:XB-GENE-5954079
Mus musculus	14939	Xenbase:XB-GENE-5954079	MOUSE14727
Mus musculus	14940		MOUSE14726
Mus musculus	14941	Xenbase:XB-GENE-5954079	MOUSE14721
Mus musculus	14942	Xenbase:XB-GENE-5954079	MOUSE14720
Mus musculus	14943	Xenbase:XB-GENE-5954079	MOUSE14725

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements