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growth differentiation factor 3

Summary

Gene Symbol

gdf3

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

30125

PubChem

30125

Alliance of Genome Resources

ZFIN:ZDB-GENE-980526-389

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Growth factor
Mitogen
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P35621
A0A8M9PNK2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

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GO Term	Evidence Code	PMID
regulation of nodal signaling pathway	IMP	23791819
nodal signaling pathway	IMP	29140250 29140251
axis specification	IMP	29140249
BMP signaling pathway	IMP	29140250
convergent extension involved in gastrulation	IGI IMP	24892953

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

activin receptor signaling pathway [inference]

nodal signaling pathway

cellular developmental process [inference]

cell development [inference]

neuron development

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

left/right pattern formation

axis specification

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

embryonic morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

convergent extension involved in gastrulation

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

convergent extension [inference]

convergent extension involved in gastrulation

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

anatomical structure development [inference]

cell development [inference]

neuron development

cellular developmental process [inference]

cell development [inference]

neuron development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of activin receptor signaling pathway [inference]

regulation of nodal signaling pathway

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell division

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of activin receptor signaling pathway [inference]

regulation of nodal signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of morphogenesis of an epithelium [inference]

regulation of epiboly involved in gastrulation with mouth forming second

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

activin receptor signaling pathway [inference]

nodal signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of activin receptor signaling pathway [inference]

regulation of nodal signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell division

regulation of cell division [inference]

positive regulation of cell division

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein-containing complex	IPI	29140251
extracellular space	IBA
extracellular region	IEA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
growth factor activity	IEA
cytokine activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050545	visceral heterotaxy	Alliance of Genome Resources
DOID:0060772	multiple types of congenital heart defects 6	Alliance of Genome Resources
DOID:0060838	isolated microphthalmia 7	Alliance of Genome Resources
DOID:0060850	annular pancreas	Alliance of Genome Resources
DOID:0080591	Klippel-Feil syndrome 3	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:1682	congenital heart disease	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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International Collaboration

Acknowledgements