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Guidelines

MIRAGE

H3.3 histone A

Summary

Gene Symbol

H3-3A

Organism

Homo sapiens (human)

External Links

NCBI Gene

3020

PubChem

3020

Alliance of Genome Resources

HGNC:4764

JoGo

H3-3A

TogoVar

H3-3A

Annotation

Keyword

3D-structure
ADP-ribosylation
Acetylation
Citrullination
Direct protein sequencing
Disease variant
Hydroxylation
Intellectual disability
Isopeptide bond
Lipoprotein
Methylation
Nucleosome core
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P84243
B2R4P9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
oocyte maturation	IEA
osteoblast differentiation	IEA
nucleosome assembly	IDA	21636898
nucleosome assembly	IMP	25615412
nucleus organization	IEA

GO Hierarchy

biological process

cellular process [inference]

cell population proliferation

cellular process involved in reproduction in multicellular organism [inference]

oocyte maturation

germ cell development [inference]

spermatid development

cellular developmental process [inference]

cell differentiation [inference]

cell development [inference]

germ cell development [inference]

spermatid development

cell maturation [inference]

oocyte maturation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

nucleus organization

chromosome organization [inference]

telomere organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

nucleosome assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

nucleosome assembly

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

nucleosome organization [inference]

nucleosome assembly

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

heterochromatin organization [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

protein-DNA complex assembly [inference]

nucleosome assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

oocyte maturation

germ cell development [inference]

spermatid development

reproductive structure development [inference]

gonad development [inference]

male gonad development

embryo implantation

fertilization [inference]

single fertilization

cellular process involved in reproduction in multicellular organism [inference]

oocyte maturation

germ cell development [inference]

spermatid development

multicellular organismal process [inference]

multicellular organism growth

developmental process [inference]

developmental process involved in reproduction [inference]

oocyte maturation

germ cell development [inference]

spermatid development

reproductive structure development [inference]

gonad development [inference]

male gonad development

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

oocyte maturation

anatomical structure development [inference]

cell development [inference]

germ cell development [inference]

spermatid development

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

cellular developmental process [inference]

cell differentiation [inference]

cell development [inference]

germ cell development [inference]

spermatid development

cell maturation [inference]

oocyte maturation

growth [inference]

developmental growth [inference]

multicellular organism growth

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell growth

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of chromosome condensation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of centromere complex assembly

positive regulation of cellular process [inference]

positive regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of chromosome condensation

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of chromosome condensation

regulation of chromosome organization [inference]

regulation of chromosome condensation [inference]

negative regulation of chromosome condensation

regulation of centromere complex assembly

negative regulation of chromosome organization [inference]

negative regulation of chromosome condensation

regulation of protein-containing complex assembly [inference]

regulation of centromere complex assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of chromosome condensation

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	IDA	20110566
nucleosome	IDA	14718166 19633671 21636898 25615412
inner kinetochore	IEA
Barr body	IEA
extracellular region	TAS

GO Hierarchy

cellular component

protein-containing complex

inner kinetochore

protein-DNA complex [inference]

nucleosome

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

nuclear chromosome [inference]

Barr body

sex chromosome [inference]

X chromosome [inference]

Barr body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

nuclear chromosome [inference]

Barr body

sex chromosome [inference]

X chromosome [inference]

Barr body

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	19633671
RNA polymerase II core promoter sequence-specific DNA binding	IDA	19633671
protein binding	IPI	19494831 19834512 20110566 20211137 20448663 20504901 20651253 20953165 23075851 23142979 24183680 24209620 24590075 24981860 25416956 26167883 26439302 32296183 33857403 33961781
structural constituent of chromatin	IDA	14718166
nucleosomal DNA binding	IDA	19633671

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of chromatin

binding [inference]

protein binding

protein dimerization activity [inference]

protein heterodimerization activity

protein-containing complex binding [inference]

chromatin binding [inference]

chromatin DNA binding [inference]

nucleosomal DNA binding

nucleosome binding [inference]

nucleosomal DNA binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

transcription regulatory region nucleic acid binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

core promoter sequence-specific DNA binding [inference]

RNA polymerase II core promoter sequence-specific DNA binding

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

core promoter sequence-specific DNA binding [inference]

RNA polymerase II core promoter sequence-specific DNA binding

chromatin DNA binding [inference]

nucleosomal DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

core promoter sequence-specific DNA binding [inference]

RNA polymerase II core promoter sequence-specific DNA binding

Gene Ontology information from NCBI Gene and UniProt.

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Last updated: April 6, 2026