GlyCosmos Portal

Submissions

smoothened, frizzled class receptor

Summary

Gene Symbol

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

30225

PubChem

30225

Alliance of Genome Resources

ZFIN:ZDB-GENE-980526-89

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5RH73

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 71 in total

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GO Term	Evidence Code	PMID
vasculogenesis	IMP	18377889
neural plate morphogenesis	IMP	16502420
negative regulation of protein phosphorylation	ISS
heart looping	IMP	21558385
cardiac ventricle development	IMP	21558385

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway

smoothened signaling pathway

G protein-coupled receptor signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification [inference]

spinal cord motor neuron cell fate specification

cell differentiation [inference]

vasculogenesis

cell differentiation in spinal cord [inference]

spinal cord motor neuron differentiation

somatic motor neuron differentiation

neuron differentiation

central nervous system neuron differentiation [inference]

spinal cord motor neuron differentiation

somatic motor neuron differentiation

epithelial cell differentiation [inference]

endothelial cell differentiation [inference]

cardiac endothelial cell differentiation [inference]

endocardial cell differentiation

cardiocyte differentiation [inference]

cardiac endothelial cell differentiation [inference]

endocardial cell differentiation

cardioblast differentiation

mesenchymal cell differentiation [inference]

neural crest cell differentiation

stem cell differentiation [inference]

cell fate commitment [inference]

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

blood vessel endothelial cell fate commitment [inference]

arterial endothelial cell fate commitment

cell development [inference]

glial cell development

oligodendrocyte development

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

striated muscle cell development

cell motility [inference]

cell migration [inference]

angioblast cell migration [inference]

angioblast cell migration from lateral mesoderm to midline

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

supramolecular fiber organization [inference]

myofibril assembly

multicellular organismal process [inference]

pattern specification process

regionalization [inference]

anterior/posterior pattern specification

dorsal/ventral pattern formation [inference]

forebrain dorsal/ventral pattern formation

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic digestive tract morphogenesis

swim bladder morphogenesis

cerebellum morphogenesis

appendage morphogenesis [inference]

fin morphogenesis [inference]

medial fin morphogenesis [inference]

caudal fin morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis [inference]

aorta morphogenesis [inference]

dorsal aorta morphogenesis

semicircular canal morphogenesis

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

embryonic morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

morphogenesis of embryonic epithelium [inference]

neural plate morphogenesis

embryonic organ morphogenesis [inference]

embryonic digestive tract morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium [inference]

neural plate morphogenesis

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

floor plate formation

tube formation [inference]

epithelial tube formation

anatomical structure development [inference]

cardiac chamber development [inference]

cardiac ventricle development

tissue development [inference]

epithelium development [inference]

somite development

muscle tissue development [inference]

smooth muscle tissue development

cell development [inference]

glial cell development

oligodendrocyte development

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

striated muscle cell development

animal organ development [inference]

sensory organ development [inference]

eye development [inference]

camera-type eye development [inference]

embryonic camera-type eye development

embryonic organ development [inference]

embryonic camera-type eye development

gland development [inference]

exocrine pancreas development

system development [inference]

muscle structure development [inference]

muscle organ development

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification [inference]

spinal cord motor neuron cell fate specification

cell differentiation [inference]

vasculogenesis

cell differentiation in spinal cord [inference]

spinal cord motor neuron differentiation

somatic motor neuron differentiation

neuron differentiation

central nervous system neuron differentiation [inference]

spinal cord motor neuron differentiation

somatic motor neuron differentiation

epithelial cell differentiation [inference]

endothelial cell differentiation [inference]

cardiac endothelial cell differentiation [inference]

endocardial cell differentiation

cardiocyte differentiation [inference]

cardiac endothelial cell differentiation [inference]

endocardial cell differentiation

cardioblast differentiation

mesenchymal cell differentiation [inference]

neural crest cell differentiation

stem cell differentiation [inference]

cell fate commitment [inference]

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

blood vessel endothelial cell fate commitment [inference]

arterial endothelial cell fate commitment

cell development [inference]

glial cell development

oligodendrocyte development

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

striated muscle cell development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway

smoothened signaling pathway

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	IBA
plasma membrane	IEA
cilium	ISS	16136078
cilium	IDA	27113758

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell projection

plasma membrane bounded cell projection [inference]

cilium

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

cilium

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IEA
G protein-coupled receptor activity	IEA
patched binding	IBA
oxysterol binding	IDA	24171105
protein kinase A catalytic subunit binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

patched binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein kinase A catalytic subunit binding

protein kinase A binding [inference]

protein kinase A catalytic subunit binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

oxysterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

oxysterol binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

G protein-coupled receptor activity

molecular sequestering activity [inference]

protein sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

smoothened

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
cell surface receptor signaling pathway
central nervous system development
commissural neuron axon guidance
patched binding
pattern specification process
smoothened signaling pathway
tissue development

Displaying **all 6** entries
InterPro
Frizzled cysteine-rich domain superfamily
Frizzled domain
Frizzled/Smoothened, 7TM
Frizzled/secreted frizzled-related protein
GPCR, family 2-like, 7TM
Smoothened, 7TM

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6608	Xenbase:XB-GENE-487420	HUMAN91271
Rattus norvegicus	25273	Xenbase:XB-GENE-487420	RATNO29746
Xenopus tropicalis	30225	Xenbase:XB-GENE-487420
Xenopus tropicalis	33196	Xenbase:XB-GENE-487420
Mus musculus	319757	Xenbase:XB-GENE-487420	MOUSE50165
Pan troglodytes	463718		PANTR41387
Bos taurus	539308		BOVIN28409
Macaca mulatta	701334		MACMU30995
Monodelphis domestica	100015195		MONDO34987
Ornithorhynchus anatinus	100078770		ORNAN01136

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements