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Submissions

ectonucleotide pyrophosphatase/phosphodiesterase 7

Summary

Gene Symbol

Enpp7

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

303729

PubChem

303729

Alliance of Genome Resources

RGD:1359324

Annotation

Keyword

Cell membrane
Direct protein sequencing
Glycoprotein
Hydrolase
Lipid metabolism
Metal-binding
Reference proteome
Signal
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5EZ72	Alkaline sphingomyelin phosphodiesterase Intestinal alkaline sphingomyelinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 9** of 9 in total

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1

2
GO Term	Evidence Code	PMID
negative regulation of cell population proliferation	ISO
regulation of intestinal lipid absorption	ISO ISS
positive regulation of ceramide biosynthetic process	ISO ISS
lipid digestion	ISO ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

sphingomyelin metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process

multicellular organismal process [inference]

digestion [inference]

lipid digestion

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

fatty acid homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of lipid catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phosphate metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of amide metabolic process [inference]

positive regulation of amide metabolic process [inference]

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of lipid catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

regulation of cholesterol transport [inference]

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal absorption [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

regulation of cholesterol transport [inference]

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of multicellular organismal process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phosphate metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of cellular component biogenesis [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal absorption [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of multicellular organismal process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Golgi apparatus	ISO
microvillus	ISO
plasma membrane	ISO ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
zinc ion binding	ISO ISS
phosphoric diester hydrolase activity	IDA ISO	16255717
sphingomyelin phosphodiesterase activity	IDA ISO ISS	16255717

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

sphingomyelin phosphodiesterase activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity

sphingomyelin phosphodiesterase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

ectonucleotide pyrophosphatase/phosphodiesterase family member 7

Functional Category

H: Coenzyme transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

Rhea

RHEA:19253

H₂O + a sphingomyelin

H⁺ + phosphocholine + an N-acylsphing-4-enine

Enzyme

3.1.4.12

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP013233
Gene Name: ectonucleotide pyrophosphatase/phosphodiesterase 7

Ortholog

Displaying entries **11 - 20** of 48 in total

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Species	Gene ID	OrthoDB
Heterocephalus glaber	101723307	10181_0:003257
Mesocricetus auratus	101842338	10036_0:001c7e
Ictidomys tridecemlineatus	101955218	43179_0:003272
Microtus ochrogaster	101980424	79684_0:001092
Chinchilla lanigera	102025145	34839_0:00402d
Peromyscus maniculatus bairdii	102910600	230844_0:002bf2
Nannospalax galili	103747306	1026970_0:003928
Fukomys damarensis	104858371	885580_0:002fbb
Dipodomys ordii	106002138	10020_0:004afd
Marmota marmota marmota	107157842	9994_0:0008c0

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements