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Guidelines

MIRAGE

coagulation factor XII

Summary

Gene Symbol

F12

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

306761

PubChem

306761

Alliance of Genome Resources

RGD:1359175

Annotation

Keyword

Disulfide bond
EGF-like domain
Fibrinolysis
Glycoprotein
Kringle
Reference proteome
Repeat
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
D3ZTE0	Hageman factor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
plasma kallikrein-kinin cascade	ISO
Factor XII activation	ISO
Factor XII activation	IEA
proteolysis	IEA
blood coagulation	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein processing

protein maturation [inference]

protein processing

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

primary metabolic process [inference]

protein metabolic process [inference]

protein processing

protein maturation [inference]

protein processing

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing

protein maturation [inference]

protein processing

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein processing

protein maturation [inference]

protein processing

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

response to topologically incorrect protein [inference]

response to misfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to misfolded protein

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of fibrinolysis

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

negative regulation of biological process [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

Factor XII activation

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

Factor XII activation

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IDA	2324612
extracellular space	IBA
extracellular space	IEA
rough endoplasmic reticulum	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

rough endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

rough endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	ISO
serine-type endopeptidase activity	IBA
serine-type endopeptidase activity	IEA
calcium ion binding	IEA
peptidase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

trypsin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
blood coagulation
hydrolase activity
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity
zymogen activation

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:2324612

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9279	hyperhomocysteinemia	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 46 in total

« First

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Chlorocebus sabaeus	103245055		CHLSB11259
Rhinopithecus roxellana	104680459		RHIRO23504
Pteropus vampyrus	105293507		PTEVA05580
Macaca nemestrina	105484051		MACNE39904
Mandrillus leucophaeus	105546704		MANLE30525
Aotus nancymaae	105726832		AOTNA36191
Dipodomys ordii	105985443		DIPOR15279
Equus asinus asinus	106827197		EQUAS21162
Rhinopithecus bieti	108544775		RHIBE20794
Phascolarctos cinereus	110216837		PHACI12386

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Last updated: December 8, 2025