GlyCosmos Portal

Submissions

helicase, lymphoid specific

Summary

Gene Symbol

HELLS

Organism

Homo sapiens (human)

External Links

NCBI Gene

3070

PubChem

3070

Alliance of Genome Resources

HGNC:4861

JoGo

HELLS

TogoVar

HELLS

Annotation

Keyword

3D-structure
Alternative splicing
Chromosome
Coiled coil
Developmental protein
Disease variant
Helicase
Mitosis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transcription regulation

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A0B4J1V9
Q76H82
A0A087WSW7
Q9NRZ9	Proliferation-associated SNF2-like protein SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6
Q0VGL2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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Last »
GO Term	Evidence Code	PMID
urogenital system development	IEA
kidney development	ISS
DNA methylation-dependent heterochromatin formation	ISS
DNA methylation-dependent heterochromatin formation	IBA
apoptotic process	IEA

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte proliferation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte proliferation

cell death [inference]

programmed cell death [inference]

apoptotic process

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation

cell division

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

heterochromatin organization [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte proliferation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

kidney development

system development [inference]

urogenital system development

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to leukemia inhibitory factor [inference]

cellular response to leukemia inhibitory factor

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

constitutive heterochromatin formation [inference]

pericentric heterochromatin formation

negative regulation of gene expression via CpG island methylation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
chromosome, centromeric region	ISS
nucleus	IBA
pericentric heterochromatin	ISS
pericentric heterochromatin	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin [inference]

heterochromatin [inference]

pericentric heterochromatin

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

chromosomal region [inference]

chromosome, centromeric region

Displaying **all 5** entries
GO Term	Evidence Code	PMID
chromatin binding	IBA
helicase activity	IEA
protein binding	IPI	22157815 32296183 32814053
ATP binding	IEA
hydrolase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

helicase

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
hydrolase activity
nucleotide binding

Displaying **all 6** entries
InterPro
Helicase superfamily 1/2, ATP-binding domain
Helicase, C-terminal domain-like
P-loop containing nucleoside triphosphate hydrolase
SNF2, N-terminal
SNF2-like, N-terminal domain superfamily
SNF2/RAD5-like, C-terminal helicase domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090011	immunodeficiency-centromeric instability-facial anomalies syndrome 4	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements