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fibroblast growth factor receptor 1a

Summary

Gene Symbol

fgfr1a

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

30705

PubChem

30705

Alliance of Genome Resources

ZFIN:ZDB-GENE-980526-255

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Immunoglobulin domain
Nucleus
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q90Z00	Basic fibroblast growth factor receptor 1-A
A0A891XJS9
A0A891XJP9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 27 in total

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GO Term	Evidence Code	PMID
positive regulation of cell differentiation	IBA
animal organ development	IEA
cardiac muscle tissue development	IMP	18045840
posterior lateral line development	IMP	19000839
cartilage development	IGI	31175226

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

cell motility [inference]

cell migration [inference]

cell migration in hindbrain

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

skin morphogenesis

post-anal tail morphogenesis

embryonic morphogenesis [inference]

olfactory placode morphogenesis

ectodermal placode morphogenesis [inference]

olfactory placode morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cranial nerve formation [inference]

olfactory nerve formation

anatomical structure development [inference]

tissue development [inference]

mesoderm development

lateral line development [inference]

posterior lateral line development

muscle tissue development [inference]

striated muscle tissue development [inference]

cardiac muscle tissue development

regeneration [inference]

tissue regeneration [inference]

fin regeneration

animal organ development

gland development [inference]

liver development

cartilage development

appendage development [inference]

fin development [inference]

pectoral fin development

limb development [inference]

pectoral fin development

growth [inference]

developmental growth [inference]

tissue regeneration [inference]

fin regeneration

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to alcohol [inference]

response to ethanol

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of developmental process [inference]

positive regulation of cell differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of developmental process [inference]

regulation of cell fate commitment [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

regulation of cell fate specification [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

regulation of endodermal cell fate specification [inference]

negative regulation of endodermal cell fate specification

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

positive regulation of cell differentiation

regulation of endodermal cell differentiation [inference]

regulation of endodermal cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

positive regulation of developmental process [inference]

positive regulation of cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

regulation of cell fate commitment [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

regulation of cell fate specification [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

regulation of endodermal cell fate specification [inference]

negative regulation of endodermal cell fate specification

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

positive regulation of cell differentiation

regulation of endodermal cell differentiation [inference]

regulation of endodermal cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
cytoplasm	IEA
Golgi apparatus	IEA
cytosol	IEA
plasma membrane	ISS	15221377

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
nucleotide binding	IEA
protein kinase activity	IEA
protein tyrosine kinase activity	IEA
transmembrane receptor protein tyrosine kinase activity	IEA
GPI-linked ephrin receptor activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

binding [inference]

protein binding [inference]

growth factor binding [inference]

fibroblast growth factor binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

sulfur compound binding [inference]

heparin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

collagen receptor activity [inference]

protein tyrosine kinase collagen receptor activity

neurotrophin receptor activity [inference]

brain-derived neurotrophic factor receptor activity

protein-hormone receptor activity [inference]

insulin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

fibroblast growth factor receptor A

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
fibroblast growth factor receptor activity
nucleotide binding
transmembrane receptor protein tyrosine kinase activity

Displaying entries **11 - 12** of 12 in total

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InterPro
Tyrosine-protein kinase, active site
Tyrosine-protein kinase, catalytic domain

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2260	Xenbase:XB-GENE-1018554	HUMAN93469
Drosophila melanogaster	2261	FB:FBgn0010389
Drosophila melanogaster	2263	FB:FBgn0010389
Drosophila melanogaster	2264	FB:FBgn0010389
Xenopus tropicalis	14182	Xenbase:XB-GENE-1018554
Drosophila melanogaster	14183	FB:FBgn0010389
Drosophila melanogaster	14186	FB:FBgn0010389
Drosophila melanogaster	25022	FB:FBgn0010389
Drosophila melanogaster	25114	FB:FBgn0010389
Xenopus tropicalis	30705	Xenbase:XB-GENE-1018554

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