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Guidelines

MIRAGE

complement factor H related 2

Summary

Gene Symbol

CFHR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3080

PubChem

3080

Alliance of Genome Resources

HGNC:4890

JoGo

CFHR2

TogoVar

CFHR2

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disulfide bond
Glycoprotein
Proteomics identification
Reference proteome
Repeat
Secreted
Signal
Sushi

Proteins

Displaying **all 5** entries
UniProt	Protein Name
P36980	DDESK59 H factor-like 3 H factor-like protein 2
A0A3B3IS28
A0A3B3ISW6
A0A3B3IRW0
A0A8V8TQS1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
complement activation	IBA
negative regulation of protein binding	IMP	23487775
cytolysis by host of symbiont cells	IMP	23487775

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

cellular process [inference]

cell killing [inference]

killing of cells of another organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

response to other organism [inference]

defense response to other organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

immune response [inference]

humoral immune response [inference]

complement activation

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of protein binding

regulation of binding [inference]

regulation of protein binding [inference]

negative regulation of protein binding

negative regulation of binding [inference]

negative regulation of protein binding

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IBA
protein-containing complex	IDA	23487775

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
complement component C3b binding	IBA
protein binding	IPI	23487775 23728178 24260121 31273197 33961781
identical protein binding	IPI	23487775 23728178 24260121

GO Hierarchy

molecular function

binding [inference]

protein binding

opsonin binding [inference]

complement component C3b binding

complement binding [inference]

complement component C3b binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

complement factor h-related protein

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
InterPro
Sushi/SCR/CCP domain
Sushi/SCR/CCP superfamily

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026