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adhesion G protein-coupled receptor E2

Summary

Gene Symbol

ADGRE2

Organism

Homo sapiens (human)

External Links

NCBI Gene

30817

PubChem

30817

Alliance of Genome Resources

HGNC:3337

Annotation

Keyword

3D-structure
Alternative splicing
Autocatalytic cleavage
Calcium
Cell adhesion
Cell membrane
Cell projection
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
G-protein coupled receptor
Glycoprotein
Inflammatory response
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0JNV7
Q9UHX3	EGF-like module receptor 2 EGF-like module-containing mucin-like hormone receptor-like 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
granulocyte chemotaxis	IMP	17928360
cell surface receptor signaling pathway	IEA
cell migration	IMP	17928360
regulation of mast cell degranulation	IMP	26841242
cell adhesion	IMP	12829604

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis

cellular process [inference]

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

cell motility [inference]

cell migration

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune effector process [inference]

regulation of leukocyte mediated immunity [inference]

regulation of myeloid leukocyte mediated immunity [inference]

regulation of mast cell degranulation

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	TAS	15203201
ruffle membrane	IEA
plasma membrane	IBA TAS
leading edge membrane	IDA	17928360

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

leading edge membrane

ruffle membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	31273197 32296183
chondroitin sulfate binding	IMP	12829604
calcium ion binding	IEA
G protein-coupled receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

chondroitin sulfate binding

sulfur compound binding [inference]

chondroitin sulfate binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

adhesion g protein-coupled receptor l2

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cell surface receptor signaling pathway

Displaying 1 entry
InterPro
GPCR, family 2, secretin-like

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1554	vibratory urticaria	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 16 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	26364		MGI:1347095
Caenorhabditis elegans	173752		WB:WBGene00017947
Rattus norvegicus	361383		RGD:1305595
Xenopus tropicalis	448252		Xenbase:XB-GENE-950605
Pan troglodytes	455788	9598_0:004b34		PANTR17430
Macaca mulatta	654420			MACMU20207
Danio rerio	792970		ZFIN:ZDB-GENE-121214-275
Pongo abelii	100444918	9601_0:00489d		PONAB14572
Loxodonta africana	100673489			LOXAF11681
Otolemur garnettii	100964446			OTOGA00149

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Summary

External Links

Annotation

OrthoDB (Group)

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Acknowledgements