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annexin A6

Summary

Gene Symbol

ANXA6

Organism

Homo sapiens (human)

External Links

NCBI Gene

309

PubChem

309

Alliance of Genome Resources

HGNC:544

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Annexin
Calcium/phospholipid-binding
Cytoplasm
Direct protein sequencing
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0S2Z2Z6
P08133	67 kDa calelectrin Annexin VI Annexin-6 Calphobindin-II Chromobindin-20 Lipocortin VI Protein III p68 p70

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
calcium ion transport	IBA
regulation of muscle contraction	IEA
ion transmembrane transport	IMP	16605264
monoatomic ion transmembrane transport	IMP	16605264
negative regulation of sequestering of calcium ion	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

apoptotic signaling pathway

transmembrane transport [inference]

monoatomic ion transmembrane transport

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

monoatomic ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

organic substance transport [inference]

calcium ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion

regulation of cellular process [inference]

signal transduction [inference]

apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nucleus	IBA
cytoplasm	IBA
mitochondrion	IEA
lysosomal membrane	IDA	23360953
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

sarcolemma

organelle membrane [inference]

vesicle membrane

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
phosphatidylserine binding	IBA
calcium ion binding	IEA
protein binding	IPI	15576473 29636414 32296183 35063084
GTP binding	IMP	16605264
calcium-dependent phospholipid binding	IDA	2138016

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

ligand-gated monoatomic ion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

ligand-gated monoatomic ion channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity

binding [inference]

protein binding

lipid binding

steroid binding [inference]

sterol binding [inference]

cholesterol binding

phospholipid binding [inference]

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

modified amino acid binding [inference]

phosphatidylserine binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Annexin A6

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 15 in total

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Gene Ontology
GTP binding
actin filament binding
calcium channel activity
calcium ion binding
calcium-dependent phospholipid binding
cholesterol binding
chondroitin sulfate binding
growth plate cartilage chondrocyte differentiation
ligand-gated monoatomic ion channel activity
mitochondrial calcium ion homeostasis

Displaying **all 5** entries
InterPro
Annexin A6
Annexin repeat, conserved site
Annexin repeat
Annexin superfamily
Annexin

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	309	Xenbase:XB-GENE-989741
Drosophila melanogaster	8416	FB:FBgn0000084
Drosophila melanogaster	11746	FB:FBgn0000084
Drosophila melanogaster	11747	FB:FBgn0000084
Mus musculus	11749	Xenbase:XB-GENE-989741	MOUSE05829
Rattus norvegicus	79125		RATNO00067
Bos taurus	327685		BOVIN33774
Macaca mulatta	711612		MACMU38301
Monodelphis domestica	100029403		MONDO09186
Ornithorhynchus anatinus	100075651		ORNAN28010